Effect of sodium chloride on formation and structure of whey protein isolate/hyaluronic acid complex and its ability to loading curcumin

Zhong, Weigang; Zhang, Tiehua; Dong, Chao; Li, Jiatong; Dai, Jingwen; Wang, Cuina

doi:10.1016/j.colsurfa.2021.127828

Cited by 18 publications

(8 citation statements)

References 66 publications

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“…For instance, in the above-mentioned work regarding HA/WPI, when NaCl increases beyond 40 mm, PEC hydrophobicity and particle size start to decrease since WPI is more likely to dissociate from PECs. [142] Similarly, the particle size of HA/DEAE-D PECs was reported to go up when NaCl concentration increased from 1 mm to 0.1 m but then decreased abruptly when the salt concentration reached 1 m. [105] Such effects of ionic strength are also illustrated in Figure 7. As with pH, ionic strength is also an important parameter for evaluation when PEC systems are designed for in vivo applications since the physiological ionic strength (i.e., NaCl 0.9% or 0.15 m) is usually sufficiently high to destabilize HA-based colloidal PECs.…”

Section: Counterionsmentioning

confidence: 81%

“…For instance, in the above‐mentioned work regarding HA/WPI, when NaCl increases beyond 40 m m , PEC hydrophobicity and particle size start to decrease since WPI is more likely to dissociate from PECs. [ 142 ] Similarly, the particle size of HA/DEAE‐D PECs was reported to go up when NaCl concentration increased from 1 m m to 0.1 m but then decreased abruptly when the salt concentration reached 1 m . [ 105 ] Such effects of ionic strength are also illustrated in Figure 7.…”

Section: Preparation Of Colloidal Pecs From Hamentioning

confidence: 99%

“…During the formulation and preparation steps of colloidal PECs, different factors (e.g., C p , mixing ratio, ionic strength, starting drug amount, addition order of drugs, stirring time, and dialysis time) should be studied and optimized as they can affect drug encapsulation and release rate. [43,50,142] The effective encapsulation of drugs in PECs, that is, in molecular or amorphous state, can be verified though differential scanning calorimetry (DSC) or X-ray diffraction (XRD) techniques. [7,43,50] For encapsulation of a positively charged drug like DOX, a high n-/n+ ratio which leads to negatively charged particles should allow a better encapsulation rate due to electrostatic attraction between particles and drug molecules.…”

Section: Small Molecule Drug Deliverymentioning

confidence: 99%

“…[ 37–39,109 ] For PECs from HA and proteins, encapsulation of a hydrophobic drug like CUR can also be improved with an adequate NaCl concentration due to enhanced hydrophobic force with “salting‐out” effect, as reported for colloidal PECs from HA and WPI. [ 142 ] Physical coating of PECs with PEG might also reduce the leakage of hydrophobic drugs and therefore enhance their encapsulation, as suggested by Xu et al in their work regarding CUR encapsulation in HA/CTS PECs. [ 44 ] By using HA functionalized with thermosensitive amphiphilic polyethers, that is, poly(ethylene oxide)‐ co ‐poly(propylene oxide) (PEO‐PPO), Le et al also found that the encapsulation of CUR in PECs can be improved by controlling complexation temperature.…”

Section: Applications Of Colloidal Pecs From Hamentioning

confidence: 99%

“…This is suggested by Zhong et al after remarking a larger particle size of PECs from HA and WPI with more hydrophobic interactions within these PECs when NaCl concentration is increased from 0 to 30 mm. [142] However, an extremely high ionic strength can prevent PEC formation or cause PEC disintegration because the electrostatic attraction between oppositely charged polyelectrolytes (short-range attractive force) is also reduced as charge screening takes place at molecular level. [87,143] Changes in phase behavior as well as average particle size of colloidal PEC systems are thus the net result of the two contradictory effects of charge screening at particle and molecular levels.…”

Section: Counterionsmentioning

confidence: 99%

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Colloidal Polyelectrolyte Complexes from Hyaluronic Acid: Preparation and Biomedical Applications

Cerf

2022

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nanocomplexes, [8,9] nanocomposites, [10,11] nanoassemblies [12] and coacervates. [13,14] Such colloidal systems, especially when prepared from biopolymers, have been extensively investigated due to their promising properties for numerous applications in biomedical fields. [1] Their merits come from the combination of three aspects: nanomedicine, biomaterials, and green chemistry. With the emergence of nanomedicine, the use of nanocarriers can offer tremendous advantages in drug encapsulation and delivery, namely enhancing the chemical stability of drugs and improving drug solubility and bioavailability. [15] Due to their small size and the possibility of surface modification with biological ligands or molecular imprinting, nanocarriers can easily cross biological barriers, which have limited pore sizes (fenestrations) under 1 micron in most cases, then target and enter the tissues or cells of interest. [16,17] Due to these aspects and the possibility of controlling drug distribution and release through particle engineering, nanocarriers can thus reduce systemic side effects and enhance the therapeutic efficacy of drugs. [15] Nanosystems can also offer unique advantages for biomedical imaging with their ability of sensing, image enhancement, and incorporating concomitantly therapeutic agents for theranostics, that is, simultaneous therapeutic and diagnostic applications. [18][19][20] When constructed from biomaterials, especially naturally occurring polysaccharides or proteins, PECs can become significantly biocompatible and biodegradable with much less immunogenicity and toxicity. [21] Besides such biorelevant aspects, the elaboration of biopolymerbased PECs is also in accordance with green chemistry principles since their preparation process usually requires only gentle mixing of polyelectrolyte solutions at room temperature, which is a simple and rapid procedure without the need for chemical agents, surfactants, organic solvents or high mechanical or thermal energy. [15] Beyond the above-mentioned basic advantages, the potential of colloidal PEC systems is increased by the inherent biological and chemical properties of individual constituent polymers. Hyaluronic acid (HA), also called hyaluronan to generally mention both its acid and salt forms, has been one of the most common polyanions among several biopolymers reported so far for the elaboration of colloidal PECs. The significant attention dedicated to HA in biomedical fields is associated with its unique advantages, stemming from not only its outstanding biocompatibility but also interesting biological activities. [22] Hyaluronic acid (HA) is a naturally occurring polysaccharide which has been extensively exploited in biomedical fields owing to its outstanding biocompatibility. Self-assembly of HA and polycations through electrostatic interactions can generate colloidal polyelectrolyte complexes (PECs), which can offer a wide range of applications while being relatively simple to prepare with rapid and "green" processes. The advantages of colloidal HA-base...

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Section: Counterionsmentioning

confidence: 81%

Section: Preparation Of Colloidal Pecs From Hamentioning

confidence: 99%