Effect of sodium diclofenac on the bioavailability of amoxicillin

Bergamaschi, Cristiane de Cássia; Motta, Rogério Heládio Lopes; Franco, Gilson César Nobre; Cogo, Karina; Franz-Montan, Michelle; Ambrosano, Gláucia María Bovi; Rosalen, Pedro Luiz; Fiol, Fernando de Sá Del; Groppo, Francisco Carlos

doi:10.1016/j.ijantimicag.2006.02.005

Cited by 17 publications

(15 citation statements)

References 30 publications

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“…In the present study, we formulated the dosage of GRANULE amo + apr as 16 mg and 4 mg per kg b.w., which is consistent with the recommended dosage of Commission of Chinese Veterinary Pharmacopoeia [10]. A previous study demonstrated a significant reduction of bioavailability and 18.5% increase in renal clearance after oral administration of AMO combined with sodium diclofenac [18]. In contrast, our study showed that the AMO-APR granular premix possesses the same pharmacokinetic characteristics (t 1/2λ , C max , T max , AUC INF , MRT) when compared to the single-ingredient powdered form of each antibiotic (Tables 1 and 2).…”

Section: Discussionsupporting

confidence: 86%

Pharmacokinetics and relative bioavailability of an oral amoxicillin-apramycin combination in pigs

et al. 2017

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A new compound granular premix of amoxicillin (20% w/w dry mass)/apramycin (5% w/w dry mass) was developed, and its pharmacokinetics and relative bioavailability were determined in pigs following oral administration following a cross-over study design. The pharmacokinetic parameters of amoxicillin (t1/2λ = 6.43 ± 4.85h, Cmax = 3.2 ± 1.35 μg·mL-1, Tmax = 1.92 ± 0.58, AUCINF = 8.98 ± 2.11 h·μg·mL-1) and apramycin (t1/2λ = 8.67±4.4h, Cmax = 0.23 ± 0.12 μg·mL-1, Tmax = 2.25 ± 0.82 h, AUCINF = 12.37 ± 8.64h·μg·mL-1) when administered as the amoxicillin-apramycin granular premix did not significantly differ from those for the single-ingredient powder form of each component. The relative bioavailability of amoxicillin following oral administration of the amoxicillin-apramycin granular premix was 22.62% when compared to the intramuscular administration of commercial amoxicillin sodium-powder. This is the first report of a new amoxicillin-apramycin combination which has a potential veterinary application the for prevention and treatment digestive tract infections in pigs.

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Section: Discussionsupporting

confidence: 86%

Pharmacokinetics and relative bioavailability of an oral amoxicillin-apramycin combination in pigs

et al. 2017

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“…Diclofenac was reported to have antibacterial activity, which was proved by studies on synthesized DNA (Dastidar et al, 2000). It was reported to treat ureteral colic (de Cássia Bergamaschi et al, 2006), Salmonella infection (Dutta et al, 2007a), tuberculosis (Dutta et al, 2007b) and used in the treatment of urinary infections, which were due to Escherichia coli (Mazumdar et al, 2006).…”

Section: Diclofenacmentioning

confidence: 99%

“…Diclofenac-induced hepatotoxicity is also reported in various studies at the dose 13.5 mg kg À1 b.w. (de Cássia Bergamaschi et al, 2006). Scientist have studied the outcome of hepatotoxicity on the oral usage of diclofenac at the dose 9.5 mg kg À1 b.w.…”

Section: Diclofenac-induced Toxicitymentioning

confidence: 99%

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Simon

Sabina

2016

J of Applied Toxicology

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The liver is an important organ of the body, which has a vital role in metabolic functions. The non-steroidal anti-inflammatory drug (NSAID), diclofenac causes hepato-renal toxicity and gastric ulcers. NSAIDs are noted to be an agent for the toxicity of body organs. This review has elaborated various scientific perspectives of the toxicity caused by diclofenac and its mechanistic action in affecting the vital organ. This review suggests natural products are better remedies than current clinical drugs against the toxicity caused by NSAIDs. Natural products are known for their minimal side effects, low cost and availability. On the other hand, synthetic drugs pose the danger of adverse effects if used frequently or over a long period. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Table I shows that there was no significant (p>0.05) difference between the subjects of two study groups in respect of age and weight. 25 . The C max observed in the present study after oral administration was modestly higher in case of Tribal and lower in case of Bangalee Bangladeshi in relation to the findings of the previous studies.…”

Section: Resultsmentioning

confidence: 99%