Effect of sodium fluoride on the oviductal mucosa of adult albino rats and the possible protective role of pomegranate peel extract

El-Abd, Shereen S; Ibrahim, Marwa A.

doi:10.1097/01.ehx.0000490003.71440.40

Cited by 2 publications

(7 citation statements)

References 48 publications

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“…Thus, protects the digestive tract against injury, it also improves blood supply and stimulates the release of VEGF. In consonant with our results, several researches [8,12] attributed the anti-inflammatory effect of pomegranate to the down regulation of cytokines such as TNF-α, IL-1, and IL-6. In addition, the preventative effect of pomegranate could be related to its flavonoids and polyphenolic contents, which had intense anti-oxidative activity and inhibited of lipid peroxidation and nitric oxide production [8,39] .…”

Section: Discussionsupporting

confidence: 91%

“…Nowadays, dietary antioxidants of natural products are considered as promising alternative therapy and may have several health benefits [1] . The pomegranate (Punica granatum L.) is vastly cultivated in Mediterranean countries as Egypt, Turkey, Tunisia, Spain, and Morocco [8,9] . It is consumed fresh, and in other forms "e.g.…”

Section: Introductionmentioning

confidence: 99%

“…juice, oil", besides, the extract supplements can also be used [10] . Pomegranate is rich in antioxidant of polyphenolic class which includes tannins and anthocyanins and flavonoids [8] . Its antioxidant capacity is 3-fold higher than that of the same amount of green tea or red wine.…”

Section: Introductionmentioning

confidence: 99%

“…Its antioxidant capacity is 3-fold higher than that of the same amount of green tea or red wine. Moreover, the antioxidant capacity of pomegranate peel extract is 10 times higher than pulp extract [8,[10][11][12] . Moreover, pomegranate is a valuable source of many vitamins as A, C, and E and folic acid.…”

Section: Introductionmentioning

confidence: 99%

“…It also exerts antiatherogenic, anticarcinogenic, anti-inflammatory, antidiarrheal, antimicrobial effects and antidiabetic activities. In addition, the pomegranate has significant role on spermatogenesis and ovulation [8,10,13] .…”

Section: Introductionmentioning

confidence: 99%

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Comparative study of the therapeutic effect of pomegranate alone or in combination with bone marrow mesenchymal stem cells on experimentally induced gastric ulcer in adult male rats: A histological and immunohistochemical study

El-Azab

Mansy

El-Mahalaway

et al. 2018

Egyptian Journal of Histology

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Introduction: Gastric ulcers are the most prevalent gastrointestinal disorders. Pomegranate fruits have many beneficial therapeutic effects. Bone marrow mesenchymal stem cells (BMSCs) are a novel approach with promising therapeutic potential for curing human diseases. Aim of the work: To evaluate the effect of pomegranate and BMSCs on experimentally induced gastric ulcer in adult male rats. Materials and Methods: Sixty adult male rats were divided into four groups. Group I kept as the control group. Group II (Gastric ulcer), rats received 100% ethanol orally by gastric tube. Group (III) subdivided into 3 subgroups. Subgroup IIIa included rats with gastric ulcer that treated with pomegranate only. Subgroup IIIb, rats with gastric ulcer treated with BMSCs alone. Subgroup IIIc; gastric ulcer rats treated with a combination of pomegranate and BMSCs. Group IV included the untreated gastric ulcer rats. Fundus of stomach specimens were prepared and examined using histological and immunohistochemical techniques. Results: Groups II and IV showed various changes as deep erosion, marked damage of most of the cells. The presence of the inflammatory cells in gastric mucosa were supported by a significant increase of tumor necrosis factor α (TNF-α) expression and collagen fibers depositions (P<0.01). A significant decrease of Periodic Acid Schiff (PAS) positive reaction and vascular endothelial growth factor (VEGF) expression was observed (P<0.01). Subgroup IIIa showed attenuation of some histological changes, while subgroups IIIb and IIIc revealed more improvement of the histological and immunohistochemical changes described before. Conclusion: BMSCs can ameliorate experimentally-induced gastric injury in rats and protect the gastric tissue. Addition of pomegranate to BMSCs can lead to better results.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative study of the therapeutic effect of pomegranate alone or in combination with bone marrow mesenchymal stem cells on experimentally induced gastric ulcer in adult male rats: A histological and immunohistochemical study

El-Azab

Mansy

El-Mahalaway

et al. 2018

Egyptian Journal of Histology

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Effect of Pomegranate Peel Extract on Submandibular Salivary Glands of Streptozotocin-Induced Diabetes in Rats: Histological, Immunohistochemical and Ultrastructural Study

Mahmoud

2017

JABB

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Purpose: Diabetes mellitus is a significant healthcare problem concern worldwide. It has different pathological effects on body tissues and organs especially on the major salivary glands. Pomegranate considers a native fruit that contains numerous polyphenolic antioxidant ingredients when compared to other fruits and vegetables. The aim of the current study was to explore the biological impact of Pomegranate Peel Extract on streptozotocin induced diabetes in submandibular salivary gland of albino rats. Methods: 30 male adult albino rats were separated into 3 groups: Group I (control), group II (diabetic group without any treatment), group III (diabetic group + Pomegranate Peel Extract). Diabetes induction was done by single intraperitoneal (i.p.) injection of streptozotocin. Plasma

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Effect of sodium fluoride on the oviductal mucosa of adult albino rats and the possible protective role of pomegranate peel extract

Cited by 2 publications

References 48 publications

Comparative study of the therapeutic effect of pomegranate alone or in combination with bone marrow mesenchymal stem cells on experimentally induced gastric ulcer in adult male rats: A histological and immunohistochemical study

Comparative study of the therapeutic effect of pomegranate alone or in combination with bone marrow mesenchymal stem cells on experimentally induced gastric ulcer in adult male rats: A histological and immunohistochemical study

Effect of Pomegranate Peel Extract on Submandibular Salivary Glands of Streptozotocin-Induced Diabetes in Rats: Histological, Immunohistochemical and Ultrastructural Study

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