Effect of sodium selenite on synaptic plasticity and neurogenesis impaired by hypothyroidism

Abatement of the dysfunctional hypothalamic–pituitary–gonadal axis due to ciprofloxacin administration by selenium in male rats

“…[ 31,32 ] Moreover, the selected doses of selenium have been established in the literature to effectively protected against oxidative damage, prostatitis, and neurotoxicity induced by various toxicants in rats. [ 33‐35 ] The animals were weighed 24 h after the final treatment while the blood collected from the animals was processed to get the serum which was subsequently used for hormonal assays. The animals were sacrificed using light ether anesthesia.…”

Synaptic Plasticity and Cognitive Ability in Experimental Adult-Onset Hypothyroidism

“…We and other investigators have reported that hypothyroidism markedly impairs both E-LTP and L-LTP in area CA1 (Figs 1A and 1B) without significantly affecting those of the DG area of thyroidectomized rats (Gerges et al, 2005(Gerges et al, , 2001Alzoubi et al, 2005Alzoubi et al, , 2006aAlzoubi et al, , b, 2007Alzoubi et al, , 2009Alzoubi and Alkadhi, 2007) or PTU-treated rats (Babur et al 2020). From molecular studies, we have shown that while the activity and protein levels of the phosphatase calcineurin were significantly increased in area CA1, they were markedly decreased in the DG area of thyroidectomized rats.…”

“…No significant difference was observed in the I/O relationship between control and thyroidectomized animals in the responses generated by various stimulus intensities in area CA1 and dentate gyrus (DG) of the hippocampal formation (Alzoubi et al, 2005(Alzoubi et al, , 2006bFernandez-Lamo et al, 2009;Yousef et al, 2019;Babur et al, 2020). However, at variance with these findings is a reported increase in the I/O curve of CA1 and DG areas that has been shown in brain slices from rats treated with PTU (Glombik et al, 2021).…”

“…It has been shown that the number of nascent brain cells is reduced in adult hypothyroid animals (Montero-Pedrazuela, 2006;Babur et al, 2020). At the cellular and molecular levels, cognitive symptoms of hypothyroidism are probably caused by alterations in the levels and activities of neurotransmitters and signaling molecules, which may result in disruption of synaptic plasticity.…”

“…Adult hypothyroidism impairs normal neurogenesis by causing a significant decrease in production of new cells from the SGZ of the DG area (Babur et al, 2020). Moreover, hypothyroidism interferes with proliferation and maturation of the nascent neurons (Lemkine et al, 2005;Desouza et al, 2005;Montero-Pedrazuela et al, 2006).…”