The aim of this research was to investigate the enzymes on alloxan induced hyperglycaemia in Wistar rats. Hyperglycaemic was induced by intraperitoneal injection of 150 mg/kg alloxan monohydrate. The rats were grouped into five groups of five rats each. Group 1 served as the diabetic negative control, Group 2 served as positive control and was treated with 2 mg/kg glibenclamide, while Groups 3, 4 and 5 were treated with 50, 100 and 200 mg/kg body weight of rutin respectively. Rutin was administered animals orally for a period of four weeks. At the end of the experimental period, the rats from each experimental group were sacrificed using light chloroform and sera were collected for the determination of lipid profile and liver function enzymes. decreased in the total cholesterol, triglyceride and low density lipoprotein as compared to control. However, there was a significant (p<0.05) increased in the level of high density lipoprotein when compared to diabetic control. Furthermore, there was a significant (p<0.05) decreased in the serum liver enzymes; Aspartate transaminase (AST) Alanine transaminase (ALT) and Alkaline phosphates (ALP) as compared to control. As regards to the reference drug 2mg/kg glibenclami there was a significant (p<0.05) increased in the liver enzymes function as compared to control. Conclusion, rutin has hypolipidemic effect and also decreased liver function enzymes activity on alloxan induced hyperglycaemic rats.

This research was aimed to investigate the anti micranthum on blood glucose levels and oxidative stress biomarkers such as malondaldehyde, superoxide dismutase, catalase and glutathione peroxidase on alloxan induced Diabetes in Wistar rats. Diabetes was induced using alloxan (150 mg/kg i.p). The rats w rats each. Group 1 served as the diabetic control, Group 2 received 2 mg/kg glibenclamide, while Groups 3, 4 and 5 were orally administered 100, 200 and 400 mg/kg body weight of ethanol leaf extract of Combretum micranthum tail artery and the serum was used to determine the oxidative stress biomarkers (malondaldehyde, superoxide dismutase, catalase and glutathione peroxidase).There was a significant (p in the blood glucose when compared with the diabetic control. Also there was a significant (p<0.05) decrease in the oxidative stress biomarkers when compared with the diabetic control. The preliminary phytochemical screening of the of the e glycosides, alkaloids ,terpenoids and resins. The LD conclusion Combretum micranthum reduce blood glucose levels, reactive oxygen free radicals and improved the activities of the antioxidant enzymes.

The present study examined the influence of selenium on ciprofloxacin‐mediated reproductive dysfunction in rats. The research design consisted of five groups of eight animals each. The rats were administered 135 mg/kg body weight of ciprofloxacin per se or simultaneously with selenium at 0.25 and 0.5 mg/kg for 15 uninterrupted days. Antioxidant and inflammatory indices were assayed using the testes, epididymis, and hypothalamus of the animals after sacrifice. Results revealed that ciprofloxacin treatment per se interfered with the reproductive axis as demonstrated by diminished serum hormonal levels, sperm quality, and enzymatic indices of testicular function, which were, however, abrogated following selenium co‐treatment. Besides this, administration of selenium attenuated the depletion of glutathione level, inhibition of catalase, superoxide dismutase, glutathione‐S‐transferase and glutathione peroxidase activities with a concomitant reduction in reactive oxygen and nitrogen species, and lipid peroxidation in ciprofloxacin‐treated in rats. Selenium treatment also mitigated ciprofloxacin‐mediated elevation in nitric oxide level and of myeloperoxidase activity as well as histological lesions in the animals. Overall, selenium attenuated impairment in the male reproductive axis due to ciprofloxacin treatment through abatement of inflammation and oxidative stress in rats.

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