Effect of Solanium melongena fruits supplemented diet on Hyperglycemia, Overweight, Liver function and Dyslipidemia in Male New Zealand Rabbits fed High fat and Sucrose diet

Abstract

The aim of the present study is to evaluate the effect of Solanium melongena Fruits supplemented diet on hyperglycemia, overweight, liver function and dyslipidemia in male New Zealand rabbits fed high fat and Sucrose solution diet. A qualitative phytochemical analysis of Solanium melongena fruits extract was performed using standard methods and phytochemical analysis showed presence of saponin, flavonoids, alkaloids, anthraquinones, tannins, steriods and terpenoids. A total of twenty male male New Zealand rabbits with mean weights between 489.00±8.0 to 493.00±10.5g were divided into five ( 5) groups (n=4), normal control group was fed normal rabbit chow and experimental groups were fed high fat diet and 30% sucrose solution. Body weights, blood sugar levels, key liver enzymes and lipid profile were examined, and the results demonstrated that, diet supplemented with 10% and 20% of Solanium melongena fruit possess a hypoglycemic ability, could aid weight reduction, restored liver function and acted as a good regulator of lipid profile levels.

Hypoglycemic and Antioxidant Capacity of <i>Curcuma Longa</i> and <i>Viscum Album</i> in Alloxan Induced Diabetic Male Wistar Rats

“…Enzyme activities in the tissues are often used as 'marker' to ascertain early toxic effects of administered foreign compounds to experimental animals [5,52]. ALP is a membrane bound enzyme while ALT and AST are cytosolic enzymes and high levels of ALP, ALT and AST respectively in the serum are indicators of cell membrane permeability and consequent degree of damage to the liver [5,52]. Alloxan exerts a toxic effect on pancreatic beta cells, which causes T1DM, but this effect extends to the livers [53].…”

“…The world prevalence of DM is estimated to increase from 425 million people in 2017 to 629 million by 2045 [3] and in Africa, the number of people with diabetes will increase from 14.2 million in 2015 to 34.2 million in 2040 predominantly populated in some of the region's most populous countries: South Africa, the Democratic Republic of Congo, Nigeria and Ethiopia (IDF 2015) [4]. Particularly, Type 2 DM is associated with obesity, there is hyperinsulinemia, high circulating cholesterol, triglyceride, low HDL, and alteration in the sensitivity or reactivity of vascular smooth muscle to neurotransmitters and circulating hormones, which may cause or contribute to diabetic vessel complications [5,6]. Often, complications associated with DM account for increased morbidity, disability, and mortality and represent a threat to the economies of all countries, especially the developing ones.…”

“…Currently, medicinal plants continue to play an important role in the management of DM, especially in developing countries, where many people do not have access to conventional anti-diabetic therapies and Ethnopharmacological surveys indicate that more than 1,200 plants are used in traditional medicine systems following claims of their hypoglycemic properties [5,12]. Also, according to ethnobotanical information, about 800 plants possess antihyperglycemic effect [13].…”

Effects of Alcoholic Extracted and Dry Eggplant (Solanum Melongena) on Hyperlipidemia Treatment in Rats

“…Brinjal is a good source of antioxidants such as flavonoids, anthocyanins, ascorbic acid, and proteins polyphenylene peroxidases (PPO), and it has a high moisture content and low caloric value [1,2]. Medicinally the extracts of Solanum melongena are effective against several diseases, Antidiabetic, antioxidant, hypolipidemic agent, Anti-inflammatory, and Vasodilator [3]. The condition known as hyperlipidemia or atherosclerosis, which is one of the biggest causes of death globally and is recognized to be the main risk factor for cardiovascular disease, is characterized by abnormally high lipid levels in the blood, such as fat, triglycerides, and cholesterol.…”

Untitled

“…According to ethnobotanical information, about 800 plants may possess antidiabetic potential, whereas ethnopharmacological surveys suggest that more than 1200 plants used in traditional medicine systems exhibit hypoglycaemic properties 8,9 . Azadirachta indica, Momordica charantia, Gymnema sylvestre, Syzygium cumini, and Trigonella foenum graecum are 5 such plants that are known to possess anti-hyperglycaemic and antioxidant properties [10][11][12][13][14] .…”