Effect of Solanum melongena peel extract in the treatment of arsenic-induced Bowen’s disease

Sarah, Quazi Sahely; Misbahuddin, Mir

doi:10.3329/bjp.v13i4.38273

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…The extract of S. melongena L. peel applied twice a day for 12 weeks reduced the diameter of skin lesions in arsenic-induced Bowen disease ( Sarah and Misbahuddin, 2018 ).…”

Section: Antitumor Effects Of Solanaceae Glycoalka...mentioning

confidence: 99%

Anticancer activity of glycoalkaloids from Solanum plants: A review

2022

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Cancer is still one of the main causes of death worldwide. For this reason, new compounds that have chemotherapeutic potential have been identified. One such group of substances is Solanaceae glycoalkaloids (GAs). They are natural compounds produced by plants widely used in traditional medicine for healing many disorders. Among others, GAs exhibit significant antitumor properties, for example, a strong inhibitory effect on cancer cell growth. This activity can result in the induction of tumor cell apoptosis, which can occur via different molecular pathways. The molecular mechanisms of the action of GAs are the subject of intensive research, as improved understanding could lead to the development of new cancer therapies. The genetic basis for the formation of neoplasms are mutations in protooncogenes, suppressors, and apoptosis-controlling and repair genes; therefore, substances with antineoplastic properties may affect the levels of their expression or the levels of their expression products. Therapeutic compounds can be applied separately or in combination with other drugs to increase the efficiency of cancer therapy; they can act on the cell through various mechanisms at different stages of carcinogenesis, inducing the process of apoptosis, blocking cell proliferation and migration, and inhibiting angiogenesis. This review summarizes the newest studies on the anticancer properties of solanine (SN), chaconine (CH), solasonine (SS), solamargine (SM), tomatine (TT) and their extracts from Solanum plants.

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“…The extract of S. melongena L. peel applied twice a day for 12 weeks reduced the diameter of skin lesions in arsenic-induced Bowen disease ( Sarah and Misbahuddin, 2018 ).…”

Section: Antitumor Effects Of Solanaceae Glycoalka...mentioning

confidence: 99%

Anticancer activity of glycoalkaloids from Solanum plants: A review

2022

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“…The S. melongena extract has significant beneficial effect on the treatment of Bowen's disease. The extract could inhibit cell cycle progression in S-phase, inducing progressive cell apoptosis, and ultimately cell death (Sarah and misbahuddin, 2018). Interestingly, the many components of Solanum melongena exhibit multiple activities.…”

Section: Introductionmentioning

confidence: 99%

Metabolites Identification of Chemical Constituents From the Eggplant (Solanum melongena L.) Calyx in Rats by UPLC/ESI/qTOF-MS Analysis and Their Cytotoxic Activities

et al. 2021

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Eggplant (Solanum melongena L.) Calyx is a medicinal and edible traditional Chinese medicine with anti-inflammatory, anti-oxidant, and anti-cancer properties. However, the pharmacodynamic components and metabolic characteristics remain unclear. Amide and phenylpropanoid were the two main constituents, and four amides, including n-trans-p-coumaroyltyramine (1), n-trans-p-coumaroyloctopamine (2), n-trans-p-coumaroylnoradrenline (3), n-trans-feruloyloctopamine (4), and a phenylpropanoid neochlorogenic acid (5) were selected. In this study, these five representative compounds showed cytotoxic activities on A549, HCT116, and MCF7 cells. In addition, the metabolites of 1–5 from the eggplant calyx in rats were identified. In total, 23, 37, 29, and 17 metabolites were separately characterized in rat plasma, urine, feces, and livers, by UPLC/ESI/qTOF-MS analysis. The metabolism of amides and phenylpropanoid was mainly involved in hydroxylation, methylation, glucuronidation, or sulfation reactions. Two hydroxylated metabolites (1-M2 and 2-M3) were clearly identified by comparison with reference standards. Rat liver microsome incubation experiments indicated that P450 enzymes could hydroxylate 1–5, and the methylation reaction of the 7-hydroxyl was also observed. This is the first study on the in vivo metabolism of these compounds, which lays a foundation for follow-up studies on pharmacodynamic evaluations and mechanisms.

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