The effect of solid solution temperature on microstructure and mechanical properties of plasma welded nickel-based high temperature alloy Inconel625 was investigated by solid solution treatment. The results show that after solid solution treatment at 950 ℃, chain carbides are precipitated at the austenite grain boundary of the base material. With solid solution temperature increasing, carbon chains dissolve gradually at the grain boundary. When solution temperature is higher than 1050 ℃, carbides at the grain boundary completely melt back into the matrix. At the weld, dendritic crystal and Laves phase dissolve with the increase of solid solution temperature. When the solid solution temperature is 1100 ℃, the dendritic crystal and Laves phase at the weld completely melt into the matrix and transform into cellular crystals. When the solid solution temperature is increased to 1150 ℃, the cellular crystal grows further at the weld. When the solid solution temperature is 1100℃, the comprehensive mechanical properties of the joint are the best, the tensile strength is 742.8 MPa, almost as strong as the welded 765.3 MPa, and the elongation is 43.1%, much higher than the welded 31.9%. The fracture of the sample is the ductile fracture on the base metal side, and the impact energy is the highest everywhere in the joint.