Effect of Solvent Type and Drying Method on Protein Retention in Chitosan-Alginate Microcapsules

Ahonkhai, Edith I.; Arhewoh, Ikhuoria M.; Augustine, O

doi:10.4314/tjpr.v5i2.14635

Cited by 7 publications

(6 citation statements)

References 10 publications

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“…3% w/w CaCl 2 was dissolved in the solution (for one-stage procedure), and its pH was adjusted to 5.0-5.5 with 0.1N NaOH. The chitosan solution was then filtered to remove any insoluble material and the volume adjusted to 1000 mL with distilled water (Ahonkhai et al, 2006).…”

Section: Solvent Extraction Of Kenaf Seed Oilmentioning

confidence: 99%

In-vitro evaluation of kenaf seed oil in chitosan coated-high methoxyl pectin-alginate microcapsules

Chew

Tan

Long

et al. 2015

Industrial Crops and Products

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Section: Solvent Extraction Of Kenaf Seed Oilmentioning

confidence: 99%

In-vitro evaluation of kenaf seed oil in chitosan coated-high methoxyl pectin-alginate microcapsules

Chew

Tan

Long

et al. 2015

Industrial Crops and Products

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“…Pendekatan ini dikaji secara ekstensif setelah suatu laporan menginformasikan bahwa kadar gula darah pada tikus penderita diabetes berhasil diturunkan setelah mendapat perlakuan pemberian nanopartikel insulin secara oral (Tiyaboonchai, 2003;Ahonkhai et al, 2006). Sona (2010) menginformasikan kitosan telah digunakan untuk penghantar molekul insulin dengan nanopartikel polimerik sebagai sistem pembawa.…”

Section: Pemberian Secara Peroral (Pero Ral Administration)unclassified

Chitosan nanoparticles: process and their application as drug delivery.

Irianto

Muljanah

2010

Squalen Bull. Marine Fisheries Postharvest Biotech.

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ABSTRAKKitosan memiliki potensi aplikasi yang sangat luas dan Indonesia memiliki sumber bahan baku yang cukup melimpah untuk mengolahnya, berupa cangkang kepiting dan rajungan serta kulit udang. Kitosan memiliki sifat yang sangat menguntungkan, yaitu biocompatible, biodegradable, tidak beracun, dan tidak mahal. Saat ini telah banyak penelitian pemanfaatan kitosan menjadi nanopartikel sebagai penghantar obat bagi berbagai target terapi. Nanopartikel kitosan dapat diolah dengan berbagai metode, di antaranya metode ikatan silang emulsi, presipitasi, pengeringan semprot, penggabungan droplet emulsi, gelasi ionik, reverse micellar method, dan kompleks polielektrolit. Aplikasi nanopartikel kitosan sebagai penghantar obat dapat dilakukan dengan pemberian secara parenteral, peroral, okular; sebagai vektor penghantar gen non-viral, penghantar vaksin, dan terapi fotodinamik. ABSTRACT:Chitosan Ojier meneliti kitosan hasil ekstrak kerak binatang berkulit keras, seperti udang, kepiting, dan serangga (Anon., 2008). Kitosan mempunyai banyak kegunaan, antara lain untuk flokulasi, menyembuhkan luka, penguat kertas, sarana penghantar obat dan gen serta biomaterial untuk imobilisasi, seperti biomolekul. Kitosan dan nanomagnetik kitosan telah digunakan unt uk m engadsorpsi ion Ni (II) dari lim bah electroplating. Kitosan merupakan biopolimer alami yang menarik disebabkan adanya gugus amino reaktif dan grup fungsional hidroksil. Kitosan memiliki karakteristik biokompatibilitas yang diinginkan serta kemampuan untuk meningkatkan permeabilitas membran. Oleh karenanya kitosan merupakan salah satu matriks imobilisasi yang paling menjanjikan karena memiliki kemampuan membentuk membran, sifat adhesi yang baik, harga murah, tidak beracun, kekuatan mekanis dan hidrofilisitas yang tinggi serta perbaikan stabilitas (Nakorn, 2008;Erdawati, 2008).Sumber utama untuk produksi kitosan adalah kitin dan bahan baku yang digunakan untuk mengolahnya tersedia dalam jumlah yang cukup melimpah di Indonesia, terutama cangkang kepiting dan rajungan serta kulit udang. Kitosan merupakan modifikasi polimer karbohidrat alami yang diproses melalui Ndeasetilasi parsial kitin. Unit utama pada polimer kitin adalah 2-deoksi-2-(asetilamino) glukosa. Unit tersebut diikat oleh ikatan -(1,4) glikosida yang membentuk polimer linier rantai panjang. Walaupun kitin tidak larut dalam sebagian besar pelarut, kitosan larut dalam sebagian besar larutan asam organik pada pH kurang dari 6,5 termasuk asam format, asetat, tartrat, dan sitrat. Kitosan tidak larut dalam asam fosfat dan asam sulfat. Kitosan tersedia dalam rentang berat molekul dan derajat deasetilasi yang luas. Berat molekul (BM) dan derajat deasetilasi (DD) adalah faktor utama yang mempengaruhi ukuran partikel, pembentukan partikel, dan agregasi (Tiyaboonchai, 2003).

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“…Chitosan solution (0.1% w / v ) was prepared as previously described 4 by dissolving 1g of chitosan in 500ml of distilled water containing 10ml of glacial acetic acid with the aid of a magnetic stirrer. The viscosity of the chitosan solution was reduced by digesting overnight with 2.14ml of 1% w/v sodium nitrite solution.…”

Section: Preparation Of Encapsulation Solutionsmentioning

confidence: 99%

“…Spherical droplets of alginate solution were formed with the syringe pump on which was fitted with a 22-guage flat-tipped needle (Chromatographic Specialties, Ontario, Canada) and extruded across a distance of 5cm, perpendicularly into the chitosan solution (50ml) contained in a glass Petri dish. An electrical field was created along the extrusion pathway 4 with the aid of the voltage power supply facility set to generate a current of 0.4mA and a variable voltage of 0 -30kV. The syringe pump was set at an extrusion rate of 0.5ml/ min.…”

Section: Microcapsule Productionmentioning

confidence: 99%

“…Usually, the approach is to explore the best combination of parameters and processes involved in drug production in order to achieve these goals 4 Ibuprofen is a non-steroidal anti-inflammatory drug whose major side effect is gastro-intestinal irritation. A way to reduce this effect is to encapsulate the drug which will shield the stomach directly from it following oral administration 5 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Two Techniques for the Production of Alginate-Based Microcapsules for Oral Delivery of Ibuprofen

Onuegbu¹,

Arhewoh²,

Okhamafe³

2009

Journal of Pharmaceutical Research

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A widely used approach for the microencapsulation of drugs especially for controlled drug delivery is emulsion polymerization. The purpose of this study was to comparatively evaluate chitosan-alginate microcapsules for oral delivery of ibuprofen using two techniques. Alginate-based microcapsules were prepared using the emulsion/internal gelation and electrostatic droplet generator/counter-ion coacervation methods. The effect of production parameters on the size of the microcapsules and in vitro ibuprofen release at pH 1.2 and 7.4 was determined. For emulsion/internal gelation method, the results showed that increase in stirring rate, volume of dispersion medium and viscosity of the coating materials did not significantly (p > 0.05) affect the size of the microcapsules. Microcapsules produced by the electrostatic droplets generator method had a narrower size distribution compared to the emulsion method. Drug release at pH 7.4 was considerably more than at pH 1.2, especially for uncoated microcapsules, microcapsules coated with high-viscosity (undigested) chitosan, and microcapsules prepared by the emulsion method. The encapsulation efficiencies of the two methods were similar as over 90% of ibuprofen was entrapped in each case. The two microencapsulation techniques can be applied in the microencapsulation of ibuprofen for oral delivery.

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Effect of Solvent Type and Drying Method on Protein Retention in Chitosan-Alginate Microcapsules

Abstract: Purpose: The effect of solvent used in dissolving chitosan (membrane material)

Cited by 7 publications

References 10 publications

In-vitro evaluation of kenaf seed oil in chitosan coated-high methoxyl pectin-alginate microcapsules

In-vitro evaluation of kenaf seed oil in chitosan coated-high methoxyl pectin-alginate microcapsules

Chitosan nanoparticles: process and their application as drug delivery.

Evaluation of Two Techniques for the Production of Alginate-Based Microcapsules for Oral Delivery of Ibuprofen

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