Effect of Sonication Duration and Power on Ablation Depth During MR‐Guided Focused Ultrasound of Bone

Abstract

1 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2017;46:1418-1422.

Methodology on quantification of sonication duration for safe application of MR guided focused ultrasound for liver tumour ablation

“…Before using this system, in clinical settings, it is strongly recommended to perform this protocol and report any deviations from the specifications. This recommendation is also in line with the studies conducted in literature which were mainly used for evaluation of already approved clinical systems in clinical settings [5][6][7][8][9] for maintenance purposes according to quality management system. The protocol can identify the faults in the system easily, as it is possible to observe the changes in signal information from the screen of the PicoScope.…”

“…This study differs from the other studies in literature [6][7][8], as it aims to translate science into a clinical application by following the requirements of quality management systems from the beginning. Whereas, the other published work [5][6][7][8][9] only provides information on quality assurance for the systems which already received clinical approvals, and these studies only aim to provide guidance on reliable and safe use in clinics. Vicari et al [8] also mentions the importance of pre-clinical testing, however, their study only investigates the system efficiency in pre-clinical settings with no reference to sonication duration verification.…”

“…Vicari et al [8] also mentions the importance of pre-clinical testing, however, their study only investigates the system efficiency in pre-clinical settings with no reference to sonication duration verification. Although Bucknor et al [9] investigates the duration, they investigate the combined effect of power and sonication duration for optimum clinical applications with a system which already received clinical approval. Obtaining a clinical approval for a new methodology is a very challenging task and demands evidence for safety and efficiency.…”

Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU): Technical Background and Overview of Current Clinical Applications (Part 1)

“…A commonly accepted treatment protocol for these lesions is the near-field approach, where the focus spot of HIFU is placed behind the cortical surface [29]. However, the effect of the interplay between sonication power and length of sonication on the ablation of soft tissue in front of the bone surface as well as the reached ablation depth within the bone is still under discussion [30]. As MR thermometry based on proton resonance frequency shift (PRFS) does not allow direct temperature mapping within the bone, heating of the adjacent soft tissue is commonly monitored as a secondary readout for successful heating of the bone surface (▶ Fig.…”

Percutaneous Image-Guided Treatment of Benign Musculoskeletal Tumors in Children

“…Focused ultrasound can result in tissue temperature elevations to 70 to 90°C in less than a minute. 20 This technique was recently approved for palliation of painful bone metastases and is currently only used experimentally as a treatment for painful benign musculoskeletal neoplasms. The most commonly described complication is skin burns.…”