Effect of Sophora flavescens Aiton extract on degranulation of mast cells and contact dermatitis induced by dinitrofluorobenzene in mice

Kim, Hyungwoo; Lee, Mi Ran; Lee, Guem San; An, Won Gun; Cho, Su-In

doi:10.1016/j.jep.2012.04.053

Cited by 59 publications

(39 citation statements)

References 35 publications

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“…In the case of Sophora flavescens (Ku shen) root, an extract inhibited histamine release both in vitro and in vivo [50, 51], and other experimental studies have reported anti-inflammatory effects for its constituent alkaloids matrine [52, 53] and oxymatrine [54] and for its total flavonoids [55]. Its flavonoids and chalcones both demonstrate antioxidant activity [56].…”

Section: Discussionmentioning

confidence: 99%

Add-On Effect of Chinese Herbal Medicine Bath to Phototherapy for Psoriasis Vulgaris: A Systematic Review

Zhang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Psoriasis vulgaris is the most common form of psoriasis. Phototherapy has been proven effective for psoriasis, but side effects have become a concern. Chinese herbal medicine (CHM) bath combined with phototherapy has been used in clinical settings, but the additional benefit requires evaluation. This review aims to evaluate the additional benefit and safety of adding CHM bath to phototherapy for psoriasis vulgaris. Cochrane library, PubMed, Embase, CNKI, and CQVIP were searched from their inceptions to 6 August 2012. Randomized controlled trials (RCTs) comparing CHM bath plus phototherapy to phototherapy alone for psoriasis vulgaris were included. Data was analyzed using Review Manager 5.1.0. Thirteen RCTs were included in the review, and eight were included in the meta-analysis. Meta-analysis showed higher efficacy of CHM bath plus phototherapy when compared with phototherapy alone in terms of PASI 60 (RR 1.25; 95% CI: 1.18–1.32). Mild adverse events were reported in ten studies, but these could be alleviated by reducing UV dosage or applying emollient. In conclusion, CHM bath appears to be a beneficial and safe adjunctive therapy to phototherapy for psoriasis vulgaris. However, these results should be interpreted with caution due to the low methodological quality of the included studies.

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Section: Discussionmentioning

confidence: 99%

Add-On Effect of Chinese Herbal Medicine Bath to Phototherapy for Psoriasis Vulgaris: A Systematic Review

Zhang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Extracts from S. flavescens and C. fructus showed inhibitory effects on 2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis (Kim et al, 2012;Matsuda et al, 2002). S. radix, S. herba, and C. fructus have suppressive effects on AD-like skin lesions in NC/Nga mice (Park et al, 2014a).…”

Section: Discussionmentioning

confidence: 99%

Gamisasangja-tang suppresses pruritus and atopic skin inflammation in the NC/Nga murine model of atopic dermatitis

Park

Jung

et al. 2015

Journal of Ethnopharmacology

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“…[9] Briefly, 50 g of C. atrata slough shed were immersed in 1,000 mL of methanol and sonicated for 30 minutes, after which they were extracted for 24 hours. The extract was then filtered through Whatman filter paper No.…”

Section: Methodsmentioning

confidence: 99%

“…[9] Briefly, mice were sensitized by painting 50 μL of DNFB (0.1%, v/v) in acetone: Olive oil (AOO, 4:1) onto the shaved dorsum of each animal for 3 consecutive days. Four days after sensitization, each mouse was challenged by painting 30 μL of DNFB (0.2%, v/v) in AOO onto the dorsum of both ears every 2 days.…”

Section: Methodsmentioning

confidence: 99%

Anti-inflammatory effects of Cryptotympana atrataFabricius slough shed on contact dermatitis induced by dinitrofluorobenzene in mice

Kim

Ryu

et al. 2014

Phcog Mag

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Background:The slough shed of Cryptotympana atrata Fabricius is widely used to treat skin diseases in China, Japan, and Korea.Objective:To investigate the anti-inflammatory effects of C. atrata on contact dermatitis.Materials and Methods:We investigated the effects of C. atrata methanol extract (MECA) on ear swelling, histophathological changes and cytokine production in 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis (CD) mice.Results:Topical application of MECA effectively inhibited enlargement of ear swelling (30 and 100 μ/ear, P < 0.05; 300 μg/ear, P < 0.01). MECA treatment also inhibited hyperplasia, spongiosis (100 and 300 μg/ear, P < 0.001), and immune cell infiltration (30 μg/ear, P < 0.05; 100 and 300 μg/ear, P < 0.001) induced by DNFB. In addition, treatment with MECA suppressed the increase in the levels of TNF-α (P < 0.05), IFN-g (3, 100 μg/ear, P < 0.05; 300 μg/ear, P < 0.01), and IL-6 (100 μg/ear, P < 0.05; 300 μg/ear, P < 0.01) production.Conclusion:These data suggest that MECA has the potential for use in the treatment of inflammatory skin diseases, including CD. Moreover, the results presented herein indicate that anti-inflammatory actions of MECA are mediated by decreasing production of TNF-α, IFN-γ, and IL-6 in inflamed tissues.

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Effect of Sophora flavescens Aiton extract on degranulation of mast cells and contact dermatitis induced by dinitrofluorobenzene in mice

Cited by 59 publications

References 35 publications

Add-On Effect of Chinese Herbal Medicine Bath to Phototherapy for Psoriasis Vulgaris: A Systematic Review

Add-On Effect of Chinese Herbal Medicine Bath to Phototherapy for Psoriasis Vulgaris: A Systematic Review

Gamisasangja-tang suppresses pruritus and atopic skin inflammation in the NC/Nga murine model of atopic dermatitis

Anti-inflammatory effects of Cryptotympana atrataFabricius slough shed on contact dermatitis induced by dinitrofluorobenzene in mice

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