Soybean (Glycine max L. Merrill) is one of the most important crops worldwide. In several European countries such as Germany, soybean cultivation is not traditional and as such remains to be optimized. One option to increase soybean production is to adapt and improve the seeding system. To investigate the effects of different seeding systems on seed yield, seed protein, and oil content, plant characteristics were assessed using a two-factorial (two seeding systems and four cultivars) field trial over two years (2017–2018) at two locations in southeast Germany. The seeding systems were drill (row spacing 14 cm) and precision seeding (row spacing 28 cm), and the cultivars were Viola 000, Lissabon 000, ES Mentor 00, and Orion 00. Depending on the seeding system, a seed yield of 3.8 t ha−1 dry matter (DM), 40.9% protein content (DM), and 18.8% oil content (DM) was achieved by drilling, and 3.6 t ha−1 yield (DM), 40.1% protein content (DM), and 19.1% oil content (DM) with precision seeding (average across four cultivars, two locations, and two years). No significant effects of the seeding system on all seed and plant characteristics were observed. As drilling and precision seeding did not affect the seed yield, seed protein, oil contents, and plant characteristics of soybean in this study, farmers are able to choose the seeding system which fits best into their farms and is economically most viable.