Effect of spatial frequency of stimulus on focal macular ERGs in monkeys

Yamada, Keisuke; Matsumoto, Celso Soiti; Nakatsuka, Kazuo

doi:10.1007/s10633-006-9017-x

Cited by 4 publications

(3 citation statements)

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“…Previous studies have used various ERG techniques to investigate the SF effect on retinal response [ 51 – 54 ]. Yamada and colleagues [ 54 ] applied focal macular ERG and found that the oscillatory potentials, which reflect the inner retina activity, decreased with increasing SF, and our findings are consistent with theirs. It has long been suggested that the retina has different channels which are selectively sensitive (tuned) to particular ranges of SF [ 55 – 58 ].…”

Section: Discussionmentioning

confidence: 99%

Human Electroretinal Responses to Grating Patterns and Defocus Changes by Global Flash Multifocal Electroretinogram

et al. 2015

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The electrical response of the retina was examined as a function of retinal region, using stimuli of various spatial frequencies in the first experiment. In the second experiment, the regional response of the retina to defocus at high and low spatial frequencies was investigated. Twenty three subjects were recruited for global flash multifocal electroretinogram (mfERG) in experiment 1. Black and white gratings (printed on plastic transparent sheets) of four spatial frequencies (SF), 0.24, 1.2, 2.4 and 4.8 cycle per degree were presented in front of the mfERG stimulation. The amplitudes and implicit times of the direct (DC) and induced (IC) components of mfERG responses were pooled into six concentric rings for analysis. There was low amplitude DC at low SF, which increased with increasing SF, and which decreased with increasing eccentricity. The IC was high in amplitude at all SF and reduced in amplitude with increasing eccentricity. Our findings suggested that outer and inner retina had different characteristics in processing spatial details. In experiment 2, Twenty-three young adults were recruited for mfERG measurement. The retinal electrical responses for low (0.24cpd) and high (4.8cpd) SF under fully corrected conditions of short-term negative defocus (-2D) and short term positive defocus (+2D) conditions were measured. There was a sign-dependent response to defocus in the DC response, mainly in peripheral regions. The sign dependent response at low SF was more obvious than that at high SF, and was located more peripherally. The IC response showed no clear trends for either defocus condition. The human retina seems to have a decoding system for optical defocus, which was tuned for low spatial frequency, and was located in the retinal near periphery.

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Section: Discussionmentioning

confidence: 99%

Human Electroretinal Responses to Grating Patterns and Defocus Changes by Global Flash Multifocal Electroretinogram

et al. 2015

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“…There are essentially three ways to deliver a stimulus to a specific area of the retina under fundus observation; through a fundus camera as is done with the Miyake system [ 2 – 7 ], through a slit-lamp microscope[ 8 , 9 ], or through a direct ophthalmoscope [ 10 ]. All of these methods are non-invasive and easily performed in the clinic, and several investigators have evaluated the macular function in different macular diseases with one of these methods.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Macular Function during Vitrectomy: New Approach Using Intraoperative Focal Macular Electroretinograms

et al. 2015

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PurposeTo describe a new technique to record focal macular electroretinograms (FMERGs) during vitrectomy to assess macular function.MethodsIntraoperative FMERGs (iFMERGs) were recorded in ten patients (10 eyes) who undergo vitrectomy. iFMERGs were elicited by focal macular stimulation. The stimulus light was directed to the macular area through a 25 gauge (25G) glass fiber optic bundle. Background light was delivered through a dual chandelier-type light fiber probe. Focal macular responses elicited with combinations of stimulus and background luminances were analyzed.ResultsA stimulus luminance that was approximately 1.75 log units brighter than the background light was able to elicit focal macular responses that were not contaminated by stray light responses. Thus, a stimulus luminance of 160 cd/m2 delivered on a background of 3 cd/m2 elicited iFMEGs from only the stimulated area. This combination of stimulus and background luminances did not elicit a response when the stimulus was projected onto the optic nerve head. The iFMERGs elicited by a 10° stimulus with a duration of 100 ms and an interstimulus interval of 150 ms consisted of an a-, b-, and d-waves, the oscillatory potentials, and the photopic negative response (PhNR).ConclusionsFocal ERGs with all components can be recorded from the macula and other retinal areas during vitreous surgery. This new technique will allow surgeons to assess the function of focal areas of the retina intraoperatively.

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“…(Miyake 1998 Their recording system for fmERGs was based on a fundus camera into which a focal stimulus system was integrated. Another system to record fmERGs was developed by Matsumoto et al (Choshi et al, 2003;Yamada et al, 2006) Their system is based on a slit-lamp microscope, and both the focal stimulus and fundus observation systems were integrated into the slit-lamp. With both systems, the examiner records the ERGs while monitoring the stimulus on the fundus either by an infrared television fundus camera or a slit-lamp-mounted infrared CCD camera.…”

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confidence: 99%

Objective Assessment of Local Retinal Function by Focal Macular and Multifocal Electroretinograms

Shinoda¹,

Matsumoto²,

Ohde³

2011

Electroretinograms

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Effect of spatial frequency of stimulus on focal macular ERGs in monkeys

Abstract: The OPs of the photopic macular ERGs are affected by the spatial frequency of the stimulus and are reduced by TTX, consistent with their being generated by inner retinal neurons.

Cited by 4 publications

References 29 publications

Human Electroretinal Responses to Grating Patterns and Defocus Changes by Global Flash Multifocal Electroretinogram

Human Electroretinal Responses to Grating Patterns and Defocus Changes by Global Flash Multifocal Electroretinogram

Assessment of Macular Function during Vitrectomy: New Approach Using Intraoperative Focal Macular Electroretinograms

Objective Assessment of Local Retinal Function by Focal Macular and Multifocal Electroretinograms

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