Effect of species, concentration and volume of local anesthetics on intervertebral disk degeneration in rats with discoblock

Wang, Weiheng; Xiao, Bing; Yu, Lei; Wang, Haotian; Qi, Junqiang; Xi, Yanhai; Deng, Guoying; Gu, Xin; Xu, Guohua

doi:10.1007/s00586-022-07398-2

Cited by 3 publications

(2 citation statements)

References 57 publications

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“…The etiology of iatrogenic IVD degeneration after discography is likely multifactorial, including annular puncture, IVD pressurization, and contrast medium toxicity, of which the first two directly concern discoblock as well [39]. In addition, a recent in vivo study added to the body of evidence on local anesthetics' IVD cell toxicity [40]. Considering the long-term degenerative changes after discography, we minimized the number of examined IVDs by avoiding control IVD injections.…”

Section: Discussionmentioning

confidence: 99%

Modic changes associated with greater pain relief following anesthetization of the adjacent lumbar intervertebral disc: A retrospective study of chronic low back pain patients

Korhonen¹,

Järvinen²,

Pesälä³

et al. 2022

European Journal of Radiology

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Section: Discussionmentioning

confidence: 99%

Modic changes associated with greater pain relief following anesthetization of the adjacent lumbar intervertebral disc: A retrospective study of chronic low back pain patients

Korhonen¹,

Järvinen²,

Pesälä³

et al. 2022

European Journal of Radiology

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“…Contemporary treatments cannot reverse or delay the process of IDD, and some even accelerate IDD. For example, discography [ 6 ] and discoblock [ 7 , 8 ] can significantly increase IDD. Intervertebral fusion surgery can increase IDD in adjacent segments, leading to the occurrence of adjacent segment disease (ASD) [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive Delivery of H2 through Ammonia Borane-Loaded Hollow Polydopamine for Intervertebral Disc Degeneration Therapy

Wang

Xiao

Qiu

et al. 2023

Oxidative Medicine and Cellular Longevity

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An imbalance in oxidative and inflammatory regulation is the main contributor to intervertebral disc degeneration (IDD). Hydrogen (H2) therapy is a promising antioxidation and anti-inflammatory approach. However, the key to the treatment is how to maintain the long-term effective H2 concentration in the intervertebral disc (IVD). Therefore, we developed a pH-responsive delivery of H2 through ammonia borane-loaded hollow polydopamine (AB@HPDA) for IDD therapy, which has sufficient capacity to control long-term H2 release in an acid-dependent manner in degenerative IVD. The characterization, toxicity, and pH-responsive H2 release of AB@HPDA was detected in vitro. The metabolization of AB@HPDA in the degenerated IVD was tested by in vivo imaging. The therapeutic effect of AB@HPDA on IDD was tested in vivo by X-ray, MRI, water content of the disc, and histological changes. Nuclear extracellular matrix (ECM) components, oxidative stress, and inflammation were also tested to explore potential therapeutic mechanisms. AB@HPDA has good biocompatibility at concentrations less than 500 μg/mL. The H2 release of AB@HPDA was pH responsive. Therefore, AB@HPDAs can provide efficient hydrogen therapy with controlled H2 release in response to the acidic degenerated IVD microenvironment. The metabolization of AB@HPDA in IVD was slow and lasted up to 11 days. HPDA and AB@HPDA significantly inhibited IDD, as tested by X-ray, MRI, disc water content, and histology ( P < 0.05 ). pH-responsive H2 delivery through AB@HPDAs has the potential to efficiently treat IDD by inhibiting ECM degradation and rebalancing oxidative stress and inflammation in degenerative IVDs.

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Cuproptosis related ceRNA axis AC008083.2/miR-142-3p promotes the malignant progression of nasopharyngeal carcinoma through STRN3

Feng,

Wu,

et al. 2024

PeerJ

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Background CeRNA axis is an important way to regulate the occurrence and development of Nasopharyngeal carcinoma (NPC). Although the research on inducing cuproptosis of tumor cells is in the early stage of clinical practice, its mechanism of action is still of great significance for tumor treatment, including NPC. However, the regulation mechanism of cuproptosis in NPC by ceRNA network remains unclear. Methods The ceRNA network related to the survival of nasopharyngeal carcinoma related genes was constructed by bioinformatics. Dual-luciferase reporter assay and other experiments were used to prove the conclusion. Results Our findings indicate that the AC008083.2/miR-142-3p axis drives STRN3 to promote the malignant progression of NPC. By performing enrichment analysis and phenotypic assays, we demonstrated that the changes in the expressions of AC008083.2/miR-142-3p/NPC can affect the proliferation of NPC. Mechanistically, luciferase reporter gene assays suggested that AC008083.2 acts as a ceRNA of miR-142-3p to regulate the content of STRN3. Furthermore, the regulations of STRN3 and the malignant progression of NPC by AC008083.2 depends on miR-142-3p to some extent. Conclusions Our study reveals an innovative ceRNA regulatory network in NPC, which can be considered a new potential target for diagnosing and treating NPC.

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Effect of species, concentration and volume of local anesthetics on intervertebral disk degeneration in rats with discoblock

Cited by 3 publications

References 57 publications

Modic changes associated with greater pain relief following anesthetization of the adjacent lumbar intervertebral disc: A retrospective study of chronic low back pain patients

Modic changes associated with greater pain relief following anesthetization of the adjacent lumbar intervertebral disc: A retrospective study of chronic low back pain patients

pH-Responsive Delivery of H2 through Ammonia Borane-Loaded Hollow Polydopamine for Intervertebral Disc Degeneration Therapy

Cuproptosis related ceRNA axis AC008083.2/miR-142-3p promotes the malignant progression of nasopharyngeal carcinoma through STRN3

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