Effect of Spinal Cord Stimulation on Sensory Nerve Conduction Threshold Functional Measures

Quantitative Sensory Testing in Patients With Chronic Unilateral Radicular Neuropathic Pain and Active Spinal Cord Stimulation

“…Comparing the results of this present investigation to data from the literature reveals that there are few data published concerning sensory measurements during active neurostimulation of the spinal cord. Aló and Chado published a series of 16 patients with chronic lower extremity neuropathic pain of different origins using bilateral SCS (28). Using automated electrical stimuli with 2000, 250, and 5 Hz, sensory nerve conduction thresholds of the large myelinated, small myelinated, and small unmyelinated nerve fibers were measured.…”

Sacral Nerve Root Stimulation for the Treatment of Urge Incontinence and Detrusor Dysfunction Utilizing a Cephalocaudal Intraspinal Method of Lead Insertion: A Case Report

“…It was theorized then, that if the dCSF could be “reduced” while still stimulating the T12‐S5 lumbosacral afferents selectively within the cauda equina, then SNRS might be effectively applied in those regions that were previously unresponsive to stimuli. Recent documented changes in sensory nerve conduction threshold functional measures, pre‐ and post‐SCS, appear to lend credence to this theory(20).…”

Spinal cord stimulation in chronic pain: evidence and theory for mechanisms of action

“…More recently, Mironer et al (2000) found that P-SCS also increased electrical tolerance, which interestingly correlated with P-SCS mediated pain reduction (Mironer & Somerville, 2000). While diverging evidence from Alo et al (1999) did not replicate the findings of increased electrical tolerance or correlation with pain reduction from P-SCS, they interestingly noted that P-SCS decreased electrical threshold bilaterally irrespective of pain laterality (Aló & Chado, 2000). While warmth threshold, heat pain threshold and heat pain tolerance were increased in two QST studies post P-SCS, Marchand et al (1991) further noted no change in visual light threshold or tolerance, arguing against a global mechanism for P-SCS-mediated analgesia and rather for a targeted segmental or supraspinal mechanism (Marchand et al, 1991; Ahmed et al, 2015).…”