Effect of Splenectomy on Antibody Rebound After Plasma Exchange

Reding, Raymond; White, David J.; Davies, Huw Alban; Latinne, Dominique; Délépaut, Béatrice; Lambotte, Luc; Calne, R. Y.

doi:10.1097/00007890-198907000-00033

Cited by 7 publications

(1 citation statement)

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“…The existence of anti‐donor isoagglutinins in recipient serum can induce a progressive antibody‐mediated humoral endothelial injury, which in severe cases leads to interstitial hemorrhage, obstruction of the microvascular level, and ischemic necrosis of the hepatic graft. Reinforced immunosuppression has been used in this type of patients [15] and alternatives such as splenectomy, preoperative or postoperative plasma exchange have also been reported [23] although such strategies are not risk free [24,25]. In our study there was not statistically significant difference in the treated episodes of histologically proven acute rejection between the three groups of patients.…”

Section: Discussionmentioning

confidence: 46%

Outcomes after identical and compatible orthotopic liver transplantation for fulminant hepatic failure: a single center experience in UK

et al. 2007

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Summary To analyze the outcomes between identical and compatible liver transplantation (OLT) for fulminant hepatic failure (FHF) from September 1984 to November 2005. The patients were divided in three groups; group 1 (identical), group 2 (compatible) and group 3 (incompatible), according to the donor‐recipient blood type matching. We analyzed several outcomes regarding mortality, patient and graft survival, incidence of acute graft rejection during the first postoperative month (30 days), incidence of biliary complications and indications of re‐transplantation. We also analyzed the relationship of Coomb's positive test with postoperative hemolysis to all the above mentioned factors. During the study period, 168 males and 112 females underwent their first OLT for FHF, with 37.1% overall mortality and 42.1% overall graft failure rate. The results between group 1 (203 patients) and group 2 (73 patients) were comparable. A statistically significant difference was recorded in 1 year and overall graft survival between group 1 and group 2 (P = 0.049 and log‐rank = 0.035 respectively). Coomb's positive test did not influence the outcomes. OLT in FHF can be safely carried out whether the donor organs are identical or compatible. Hemolysis (Coomb's positive test) after identical or compatible OLT does not influence the outcomes.

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Section: Discussionmentioning

confidence: 46%