Effect of Squid Cartilage Chitosan Molecular Structure on the Properties of Its Monofilament as an Absorbable Surgical Suture

Abstract

Suture is an important part of surgery, and wounds closing after surgery remains a challenge for postoperative care. Currently, silk, linen fiber, and cotton are available in the market as non-absorbable suture biomaterials. So, there is an urgent need to develop a novel suture with advantageous characteristics compared to the ones available on the market. In present study, a series of ultra-high molecular weight chitosan with different DD and MV were prepared from squid cartilage by alkaline treatment and ultrasonic degradation. The corresponding chitosan monofilaments were prepared by a wet spinning process and were characterized as sutures. The effects of the DD and MV of chitosan on the properties of its monofilament were studied, including surface morphology, mechanical property, swelling ratio, ash content, in vitro enzymatic degradation, and in vitro cytotoxicity. According to the results, AS-85 was chosen to be the best suitable as an absorbable surgical suture, which was spun from squid cartilage chitosan with DD~85% and MV~1.2 × 106. The outcome of the present study might derive tremendous possibilities for the utilization of squid cartilage β-chitin for biomedical applications.

Valorization of Bread Waste to Fungal-Based Products for Medical Textile and Food Applications

“…Chitosan scaffolds have a porous structure, enabling the enzyme to be transported to the structure of the material as well as allowing any degradation products to diffuse from the structure . The degradation of wet-spun chitosan fibers showed that chitosan with a higher degree of deacetylation had a lower degradation speed, and the lowest residual ratio achieved after 5 weeks was around 85% . Wet-spun chitin fibers, on the other hand, were reported to have a higher degradation rate, reaching down to 53% residual mass after 15 days in a lysozyme/PBS solution …”

Applications of Chitosan in Surgical and Post-Surgical Materials

“…To begin with, chitosan has been used for the development of different drug delivery systems, including mucoadhesive, multiparticulate parenteral, and floating oral drug delivery systems [26][27][28][29][30]. Moreover, chitosan has been explored for tissue engineering, sutures, and wound dressings, taking advantage of its bacteriostatic and healing properties [31][32][33][34]. Other applications include the development of biosensors [35].…”

“…These devices can be made up of a monofilament or a set of twisted or braided filaments. There are some requirements for sutures, including good mechanical properties and high biocompatibility [34,160]. Among the most frequent problems attributable to the sutures used today, the frequent infection of the tissues adjacent to the sutured wounds has recently attracted the attention of researchers.…”

“…As an example of the former, Tan et al prepared electrospun monofilaments with chitosan of different molecular weights and deacetylation degrees [34]. These devices were then characterized through various techniques, including surface morphology, mechanical properties, swelling ratio and in vitro degradation, and cytotoxicity, among others.…”

Silk nanofibrils/chitosan composite fibers with enhanced mechanical properties

“…Chitosan (CS), as a promising biopolymer, has the advantages of low cost, nontoxicity, biocompatibility, and biodegradability. CS fibers have shown broad biomedical clinical applications such as surgical sutures, [1] wound dressing, [2,3] artificial skin, [4] and 3D scaffolds for tissue engineering. [5,6] The excellent antibacterial activity and spinnability make CS very suitable for fabrics in the textile field, especially for underwear and home textiles.…”