Effect of St.John's wort (Hypericum perforatum) oily extract for the care and treatment of pressure sores; a case report

Yücel, Ali Çağın; Kan, Yüksel; Yeşilada, Erdem; Akın, Onat

doi:10.1016/j.jep.2016.12.030

Cited by 26 publications

(20 citation statements)

References 16 publications

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“…1 [62, 65–70]; 2 [53, 76–78, 138–152]; 3 [66, 68, 93, 97, 98, 100, 153–157]; 4 [158]; 5 [38, 93, 118, 119, 123–126, 157, 159–169]; 6 [170]; 7 [171]; 8 [172]; 9 [102, 103, 173]; 10 [174];; 11 [93]; 12 [93, 117–119]; 13 [167] 14 [65, 69, 175]; 15 [76, 79, 139–141, 151, 177, 178, 176, 179]; 16 [97]; 17 [120–122]; 18 [68]; 19 [78, 138, 152, 170]; 20 [68, 102, 103]; 21 [160, 166, 180]; 22 [79, 149, 150]; 23 [168, 181]; 24 [82]; 25 [35, 37, 104]; 26 [182]; 27 [29, 57–63]; 28 [31, 32, 82, 84, 87, 88, 183, 184]; 29 [104]; 30 [81]; 31 [185]; 32 [29, 64, 186]; 33 […”

Section: Resultsmentioning

confidence: 99%

Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review

et al. 2019

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Background Medicinal plants have been used traditionally since centuries for wound care and treatment of skin diseases both in human and animals. Skin diseases are one of the most common reasons for owners to take their dog to the veterinarian. The demands for treatment and prophylaxis of these diseases are broad. A wide range of bacteria including antibiotic-resistant bacteria can be involved, making the treatment challenging and bear an anthropo-zoonotic potential. The aim of this review is to systematically evaluate based on recent scientific literature, the potential of four medicinal plants to enrich the therapeutic options in pyoderma, canine atopic dermatitis, otitis externa, wounds and dermatophytosis in dogs. Results Based on four books and a survey among veterinarians specialized in phytotherapy, four medicinal plants were chosen as the subject of this systematic review: Calendula officinalis L. (Marigold) , Hypericum perforatum L. agg. (St. John’s Wort) , Matricaria chamomilla L. (syn. Matricaria recutita L., Chamomile) and Salvia officinalis L. (Sage). According to the PRISMA statement through literature research on two online databases a total of 8295 publications was screened and narrowed down to a final 138 publications for which full-text documents were analyzed for its content resulting in a total of 145 references (21 clinical, 24 in vivo and 100 in vitro references). Conclusions All four plants were proven to have antibacterial and antifungal effects of a rather broad spectrum including antibiotic-resistant bacteria. This makes them an interesting new option for the treatment of pyoderma, otitis externa, infected wounds and dermatophytosis. Marigold, St. John’s Wort and Chamomile showed wound-healing properties and are thus promising candidates in line to fill the therapeutic gap in canine wound-healing agents. St. John’s Wort and Chamomile also showed anti-inflammatory and other beneficial effects on healthy skin. Due to the wide range of beneficial effects of these medicinal plants, they should be taken into account for the treatment of dermatologic diseases in dogs at least in future clinical research. Electronic supplementary material The online version of this article (10.1186/s12917-019-1854-4) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review

et al. 2019

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“…Oleum hyperici was assessed for its potential efficacy in treating pressure sores (decubitus ulcer) in a case study with an 82 year man. The histopathological results showed progress in epithelialization and the ulcer wound area (cm) went from 4.55 × 6.57 to 1.39 × 2.73 following 32 days of twice daily treatments, bringing his Braden score from 10 to 21 in that time period [59]. Examination of the immunomodulatory potential of St. John’s Wort on the skin of human volunteers found that topical applications of ointment inhibited the allostimulatory capacity of epidermal cells and reduced their capacity to stimulate proliferation of allogeneic T cells in a mixed epidermal cell lymphocyte reaction following exposure to radiation, which may provide a rationale for the traditional treatment of inflammatory skin conditions with hypericum oil [60].…”

Section: St John’s Wort: Hypericum Perforatum L Hypericaceaementioning

confidence: 99%

Wound Healing with Botanicals: a Review and Future Perspectives

Quave

2018

Curr Derm Rep

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Purpose of Review. Botanicals have long played a crucial role in the management of chronic and infected wounds, yet the mechanistic basis of these therapies remains largely poorly understood by modern science. Recent Findings. Studies have begun to unveil the mechanistic bases of botanical therapies for wound healing, but more work is necessary. Most notably, investigation into the growing conditions, postharvest treatment and pharmacological preparation of these botanicals has demonstrated their importance in terms of the chemical makeup and pharmacological activity of the final product used in pre-clinical and clinical studies. Summary. This work evaluates the potential safety, efficacy and mechanistic basis of some key botanical ingredients used in traditional medicine for wound care: aloe, marigold and St. John’s wort. Furthermore, perspectives on the future role that botanical natural products may play in anti-infective and wound care innovations are explored.

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“…Extracts from . androsaemum, H. perforatum, H. salsugineum, and H. scabrum have shown strong wound healing properties due to the structural diversity of their active ingredients, which synergistically interact to provide an overall healing effect (Antognoni et al, 2017;Bender et al, 2018;Dikmen et al, 2010;Moghadam et al, 2019;Yücel et al, 2017). The wound healing activity of most Hypericum species, as shown in Table 1, have been associated with the stimulation of fibroblast migration, collagen production, suppression of inflammation, efficiently contributing to the wound closure of the damaged area and its reepithelialisation (Bridi et al, 2017;Moghadam et al, 2019;Süntar et al, 2011).…”

Section: Wound Healing Activitymentioning

confidence: 99%

Hypericum genus cosmeceutical application – A decade comprehensive review on its multifunctional biological properties

Silva

Taofiq

Ferreira

et al. 2021

Industrial Crops and Products

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Effect of St.John's wort (Hypericum perforatum) oily extract for the care and treatment of pressure sores; a case report

Cited by 26 publications

References 16 publications

Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review

Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review

Wound Healing with Botanicals: a Review and Future Perspectives

Hypericum genus cosmeceutical application – A decade comprehensive review on its multifunctional biological properties

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