Wound Healing with Botanicals: a Review and Future Perspectives

Quave, Cassandra L.

doi:10.1007/s13671-018-0247-4

Cited by 17 publications

(8 citation statements)

References 50 publications

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“…The 10% (w/w) gel ointment treated group revealed significant wound area contraction starting from day 9 of wounding, whereas the 5% (w/w) ointment treated group showed statistically significant wound area contraction starting from the 12th day on wards. The outcomes of topical formulation of Aloe gel at 100% of Aloe being considered most effective, and other with less than 50% showing less effect, 35 this evidence supports the result of the present study in which the 10% is more effective than 5% gel ointment in both models of wound. This implies that as leaf gel concentration increases the wound contraction rate also increases.…”

Section: Discussionsupporting

confidence: 90%

Investigation of Wound Healing and Anti-Inflammatory Activities of Leaf Gel of Aloe trigonantha L.C. Leach in Rats

Tazeze¹,

Mequanente²,

Nigussie³

et al. 2021

JIR

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Background:Traditionally Aloe trigonantha leaf is used for the treatment of different diseases. However, there were no in vivo studies which prove its claimed use for wound healing and anti-inflammatory activity. Therefore, the present study aimed at evaluating the in vivo wound healing and anti-inflammatory effects of the leaf gel of the plant in rats. Methods: The leaf gel powder of the Aloe trigonantha was prepared after the gel gets lyophilized. It was evaluated for wound healing activity topically by incorporating it in a simple ointment base at a concentration of 5% (w/w) and 10% (w/w). Excision and incision models were used for wound healing activity in rats. For the excision wound model, wound contraction and period of epithelialization were evaluated, while wound tensile strength was evaluated using an incision wound model. A Xylene-induced ear edema model and cotton pellet-induced granuloma model were used for anti-inflammatory study. The leaf gel powder of Aloe trigonantha was given orally at a dose of 100, 200, and 400 mg/kg in both models of anti-inflammatory studies. An anti-inflammatory effect was measured by reduction of ear edema weight and reduction of wet exudate and dry granuloma weight in both of xyleneinduced ear edema and cotton pellet-induced granuloma models, respectively. Results: Treatment of wounds with ointment containing 5% and 10% (w/w) of the gel exhibited a significantly increased wound contraction rate, shorter epithelialization time, and higher skin breaking strength (p<0.05) compared to controls. Aloe trigonantha leaf gel powder also produced dose-dependent significant reductions (p<0.05) of inflammation compared to control in both models. Conclusion: Data obtained from this study collectively indicated that Aloe trigonantha is a potential wound-healing and anti-inflammatory agent in rat models of wound and inflammation which provides evidence for the traditional claim.

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Section: Discussionsupporting

confidence: 90%

Investigation of Wound Healing and Anti-Inflammatory Activities of Leaf Gel of Aloe trigonantha L.C. Leach in Rats

Tazeze¹,

Mequanente²,

Nigussie³

et al. 2021

JIR

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“…However, it is currently still unclear which treatment is more appropriate in the cases of traumatic TM perforation and studies on this matter are ongoing. TV and HO are frequently used in traditional medicine due to their tissue repair-accelerating effect [18,19]. TV and HO induce the active cells in wound healing process, especially fibroblast and endothelium, and thus, affect wound healing [18,20].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effect of Triticum Vulgare and Hyperici Oleum on healing in traumatic membrane perforation: an animal study

Bora

Durmuş

İnan

et al. 2023

Egypt J Otolaryngol

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Background Traumatic tympanic membrane (TM) perforations usually heal spontaneously. The aim of this study was to investigate whether the topical application of Triticum Vulgare (TV) in experimentally induced traumatic TM perforations in the rats has a positive effect on wound healing process. Methods The rats were randomly assigned to four experimental groups. Drugs were introduced twice a day for 7 days. On the 7th day, specimens were sent for histological examination. Results Mean values found in group NC in terms of epithelial regeneration mean scores are as follows: fibroblast and collagen density, neovascularization, and density of inflammation cells were lower than all groups (p < 0.05). It was found that reepithelization on the post-perforation 7th day was better in the HO group than the TV group. In terms of the subepithelial fibroblast cells, density of collagen fibers, formation of new veins, and inflammatory cell accumulation, it was observed that the group TV was better than the group HO. Conclusion This is the first study investigating the potential curative role of TV in an experimental rat model of tympanic membrane perforation. Considering these findings, it is concluded that TV can be more effective than HO on wound healing in TM perforation.

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“…Os benefícios da utilização desse produto fitoterápico foram destacados por Quave (2018) (32) , que afirma sua atividade biológica para a cicatrização de feridas, que age como antimicrobiano, antiviral e anti-inflamatório, influenciando a fase inflamatória do processo cicatricial.…”

Section: Scopusunclassified

Tratamento de lesões nos pés de pessoas com diabetes mellitus no cenário brasileiro: revisão integrativa

Araújo

FILHO

Brandão

et al. 2022

Rev. Enferm. Atual In Derme

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Introdução: Pessoas com diabetes mellitus são mais suscetíveis a lesões cutâneas, ulceração e infecção no pé. Essas complicações são causas frequentes de internação hospitalar e elevados custos em saúde. Objetivo: Analisar os tratamentos para o pé diabético na realidade brasileira. Método: Realizou-se revisão integrativa da literatura por meio de busca nas bases de dados PubMed/MEDLINE, Scopus, Web of Science e EMBASE, baseada no método preconizado em seis etapas e construída conforme a metodologia PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Dois pesquisadores independentes realizaram a combinação de descritores Diabetic foot AND Therapeutics AND Brazil, em outubro de 2020. Foram examinados artigos publicados entre 2010 e 2020. Dos artigos selecionados, extraíram-se as informações: base de dados, autor, ano de publicação, desenho de pesquisa, tratamento e principais resultados. Resultados: Dentre os 257 artigos inicialmente identificados, foram selecionados 15. A laserterapia (26,66%), seguida da oxigenoterapia hiperbárica (13,33%) foram as formas de tratamento para pé diabético mais abordadas nos estudos brasileiros. Outras terapêuticas também foram encontradas. Todas as formas de tratamento para o pé diabético mostraram efeitos positivos sobre o processo de cicatrização da ferida, reduzindo sua extensão, área de tecido desvitalizado e a dor referida. Conclusão: a terapia com laser e a oxigenoterapia hiperbárica tem sido as principais formas de tratamento testadas e implementadas na realidade brasileira por pesquisadores e profissionais de saúde.

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Wound Healing with Botanicals: a Review and Future Perspectives

Cited by 17 publications

References 50 publications

Investigation of Wound Healing and Anti-Inflammatory Activities of Leaf Gel of Aloe trigonantha L.C. Leach in Rats

Investigation of Wound Healing and Anti-Inflammatory Activities of Leaf Gel of Aloe trigonantha L.C. Leach in Rats

Comparison of the effect of Triticum Vulgare and Hyperici Oleum on healing in traumatic membrane perforation: an animal study

Tratamento de lesões nos pés de pessoas com diabetes mellitus no cenário brasileiro: revisão integrativa

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