Effect of stage of æstrous cycle on tylosin disposition in genital tract secretions of cows

Pharmacokinetics of a Florfenicol-Tylosin Combination after Intravenous and Intramuscular Administration to Beagle Dogs

“…The pharmacokinetics of tylosin was evaluated in dogs in an earlier study [24]. The high volume of distribution of tylosin obtained in our study (1.98 l/kg) is in agreement with previous reports in dogs, rats, cow, sheep and goats [3,6,23,24], however, it is lower than that in pigs (14.6 l/kg) [18] and camels (11.9 l/kg) [26]. Tylosin is rapidly eliminated from blood after IM injection in different animal species, with the t 1/2 values ranging from 0.4 hr in rats [6] to 4.75 hr in sheep [23].…”