Effect of starvation for four days on antipyrine metabolism in calves

Abstract

Summary The effect of starvation for four days on the metabolism of antipyrine was studied in calves by measuring the antipyrine plasma clearance as well as the excretion of three major metabolites of antipyrine in urine. The study was carried out on 20 calves, females of the Holstein‐Friesian breed, (10 calves in a control group and 10 in an experimental group), aged 14–15 days. Antipyrine studies were performed in a experimental group before and after the 4 days of starvation. The starvation for four days was associated with a statistically significant (p < 0.01) increase in the plasma antipyrine elimination half‐life. In the starved calves the systemic clearance of antipyrine was significantly (p < 0.05) decreased. The excretion of the three major metabolites of antipyrine: 4‐hydroxyantipyrine, 3‐hydroxymethylantipyrine and norantipyrine in urine was significantly (p < 0.01) decreased after starvation. In the control group no significant differences between the pharmacokinetic parameters of antipyrine in 14–15 and 18‐19 day‐old calves were observed and the urinary profiles of antipyrine in calves from the control group did not differ significantly between 14–15 and 18–19 days of age. The data obtained from this study indicate that starvation for four days inhibits antipyrine elimination in calves. Zusammenfassung Der Einfluß einer viertägigen Hungerperiode auf den Antipyrinmetabolismus bei Kälbern In der vorliegenden Untersuchung sollte der Einfluß einer viertägigen Hungerperiode auf die Antipy‐rinclearance im Plasma, die Ausscheidung über die Nieren und die Nierenclearance von drei Antipyrin‐metaboliten bei Kälbern untersucht werden. Als Versuchstiere dienten 20 weibliche Holstein‐Friesian Kälber im Alter von 14–15 Tagen. Die Kälber wurden in zwei Grüppen eingeteilt (10 Kälber in der Kontrollgruppe und 10 Kälber in der Versuchsgruppe). Der Antipyrintest wurde 0 Tage und 4 Tage nach Nahrungsentzug durchgeführt. Nach viertägiger Hungerperiode war die Antipyrinhalbwertszeit (p < 0.01) wesentlich verlängert. Die Plasma‐Antipyrin‐Clearance, die Nierenausscheidung und die Nierenclearance der Antipyrin‐metabolite wurde (p < 0.01) bei viertägigem Nahrungsentzug bei den Kälbern deutlich reduziert. Aus der Kontrollgruppe geht hervor, daß sich hinsichtlich der Antipyrinhalbwertszeit, der Antipyrin‐clearance sowie der Nierenausscheidung keine wesentlichen Unterschiede zwischen 14–15 Tage alten und 18–19 Tage alten Kälbern (p > 0.05) zeigen. Ein viertägiger Nahrungsentzug reduziert demnach den Antipyrin‐Stoffwechsel wesentlich.

The effect of food or water deprivation on paracetamol pharmacokinetics in calves

“…The results of this study indicate that food or water deprivation alters the pharmacokinetics of paracetamol in calves. Similar findings were reported in calves for antipyrine (Janus et al. , 1997a) and caffeine (Janus et al.…”

“…After 4 days of food deprivation, the MRT of paracetamol was significantly increased, similar effects being reported for anti‐pyrine and caffeine in calves (Janus et al. , 1997a,2001).…”

“…An increase in the distribution volume of antipyrine after food deprivation was reported in horses by Engelking et al. (1987) and in calves by Janus et al. (1997a).…”

“…In cattle relatively little is known about the effect of food and water deprivation on drug pharmacokinetics. In previous studies we have reported the effect of short‐term starvation and water deprivation on antipyrine (Janus et al. , 1997a,b) and caffeine (Janus et al.…”

Effects of starvation on the pharmacokinetics and optimal dosages of florfenicol and associated serum biochemistry in Asian seabass (Lates calcarifer)

“…As a result, starvation can potentially exert an influence on drug pharmacokinetics (PK) (Anderson, 1988;Karimi et al, 2021;Krishnaswamy, 1978;Lammers et al, 2020). In fact, starvation-induced PK changes have been reported in many land animals such as turkey (Agbo et al, 2016), rabbit (Etuk et al, 2006), goat (Abdullah & Baggot, 1986, 1988, calve (Janus et al, 1997(Janus et al, , 2001(Janus et al, , 2003, and rat (Nakashima et al, 1987); the most consistent findings from these studies are prolonged drug elimination rates in the starved animals. Unfortunately, to the best of the author's knowledge, no similar information is available in any fish species.…”