Effect of Steamed Onion (ONIRO) Consumption on Body Fat and Metabolic Profiles in Overweight Subjects: A 12-Week Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Jeong, Sarang; Chae, Jisuk; Lee, Gahyun; Shin, Gurum; Kwon, Young‐In; Oh, Jung-Bae; Shin, Dong Yeob; Lee, Jong Ho

doi:10.1080/07315724.2019.1635052

Cited by 11 publications

(23 citation statements)

References 36 publications

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“…The number of participants in each study ranged from 12 to 92. Two studies (Kim et al, 2013; Lee et al., 2011) involved healthy adult, three studies involved hyperlipidemia subjects (Kyung Huil et al, 2007; Lee et al, 2010; Lu et al, 2015), and five studies involved Overweight and/or obesity subjects (Bruell et al., 2016; Choi et al., 2015; Jeong et al, 2019; Kim & Yim, 2015; Park et al, 2016). All the studies were published between 2007 and 2019.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…All the studies were published between 2007 and 2019. Eight trails (Choi et al., 2015; Jeong et al, 2019; Kim et al, 2013; Kim & Yim, 2015; Kyung Huil et al, 2007; Lee et al, 2010; Lee et al., 2011; Park et al, 2016) were conducted in Korea, one (Lu et al, 2015) in China and one (Bruell et al., 2016) in Germany. The duration of intervention in the included studies ranged from 2 to 12 weeks.…”

Section: Resultsmentioning

confidence: 99%

“…The duration of intervention in the included studies ranged from 2 to 12 weeks. Seven trials (Choi et al., 2015; Jeong et al, 2019; Kim & Yim, 2015; Kyung Huil et al, 2007; Lee et al., 2011; Lu et al, 2015; Park et al, 2016) were designed in parallel and three (Bruell et al., 2016; Kim et al, 2013; Lee et al, 2010) in a cross‐over design. Characteristics of the included study are summarized in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…All of the included studies mentioned randomization, but only five (Bruell et al., 2016; Choi et al., 2015; Jeong et al, 2019; Kim & Yim, 2015; Kyung Huil et al, 2007) provided specific methods for randomization. Two studies (Bruell et al., 2016; Jeong et al, 2019) adequately concealed the randomization scheme. A double‐blind design was used in seven studies (Bruell et al., 2016; Choi et al., 2015; Jeong et al, 2019; Kim et al, 2013; Kim & Yim, 2015; Kyung Huil et al, 2007; Lee et al, 2010; Lee et al., 2011; Lu et al, 2015; Park et al, 2016), blinding of outcome assessment in nine studies (Bruell et al., 2016; Choi et al., 2015; Jeong et al, 2019; Kim & Yim, 2015; Kyung Huil et al, 2007; Lee et al, 2010; Lee et al., 2011; Lu et al, 2015; Park et al, 2016) were considered as low risk of bias.…”

Section: Resultsmentioning

confidence: 99%

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Effect of onion on blood lipid profile: A meta‐analysis of randomized controlled trials

Wang

Tang

Zhang

et al. 2021

Food Science & Nutrition

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Background Studies indicate that onion supplementation may be effective in the treatment of dyslipidemia; however, the results remain controversial. This meta‐analysis was conducted to evaluate potential benefits of onion on lipid profile. Methods Up to 12 October 2020, PubMed, Cochrane Library, Web of Science, and Scopus were searched for randomized controlled trials evaluating the effects of onion on lipid profile. Mean differences (MD) and 95% confidence intervals (CI) were calculated. Meta‐analysis was conducted using the fixed‐effects model. Results Ten trials with 446 participants in total were included in the meta‐analysis. The pooled findings of 10 studies suggested that onion supplementation significantly improved high‐density lipoprotein cholesterol (HDL) (MD: 2.29 mg/dl; 95% CI: 0.87, 3.72; I2 = 0%) and low‐density lipoprotein cholesterol (LDL) (MD: −6.64 mg/dl; 95% CI: −10.91, −2.36; I2 = 32%),while onion supplementation did not significantly lower triglycerides (TG) (MD: −6.55 mg/dl; 95% CI: −15.64, 2.53; I2 = 45%). Analysis of nine trials showed a significant reduction in total cholesterol (TC) (MD: −5.39 mg/dl; 95% CI: −10.68, −0.09; I2 = 49%) in patients with onion supplementation compared to the control group. Conclusion In summary, supplementation of onion was beneficial to control dyslipidemia, including improving levels of HDL, LDL, and TC, but could not reduce TG level. The therapeutic benefits of onion for dyslipidemia need to be treated with caution considering that some of the results are not robust.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effect of onion on blood lipid profile: A meta‐analysis of randomized controlled trials

Wang

Tang

Zhang

et al. 2021

Food Science & Nutrition

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Antiobesity effects of onion (Allium cepa) in subjects with obesity: Systematic review and meta‐analysis

Chung¹,

Park

2023

Food Science & Nutrition

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Onions are rich in bioactive compounds and have been found to prevent various chronic diseases, including obesity. We performed a systematic review and meta‐analysis to investigate the antiobesity effect of onions. Studies were identified in PubMed/MEDLINE, Embase, Web of Science, and CENTRAL focusing on clinical trials evaluating the antiobesity effects of onion in obese subjects. The risk of bias in the studies was evaluated using Cochrane's Risk of Bias tool. The effect of onions was analyzed using data from the selected studies, and the results were indicated by weighted mean difference with 95% CI. The I2 static test was used to examine heterogeneity between the studies. A total of 38 studies were reviewed, of which five clinical trials meeting the criteria were selected. As investigational products, onion peels were used in four studies and onions were used in one study. Following systematic review, it was determined that the risk of bias was generally low, and body weight, BMI, waist circumference, and triglyceride levels were significantly reduced in the onion groups compared to the placebo. In conclusion, onion intake had an antiobesity effect by reducing body weight and body fat, and this effect was particularly pronounced with onion peel.

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Effect of flavonoid intake on circulating levels of adiponectin and leptin: A systematic review and meta‐analysis of randomized controlled clinical trials

Liu

Zhou

et al. 2022

Phytotherapy Research

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This meta-analysis of randomized controlled trials (RCTs) was conducted to explore the effects of flavonoid intake on adiponectin and leptin levels. The PubMed, EMBASE, and Cochrane Library databases were searched on March 1, 2021. Random-effects, subgroup, sensitivity, and meta-regression analyses were conducted on 40 publications. Flavonoid intake significantly increased circulating adiponectin (0.54 μg/ml, 95% CI [0.20, 0.88], p = .002; I 2 = 86.4%) and significantly reduced leptin levels (weighted mean difference: À0.79 ng/ml, 95% CI [À1.33, À0.25], p = .004; I 2 = 87.7%). Subgroup analysis demonstrated that flavonoid intervention produced a significant elevation in adiponectin levels only in studies that lasted more than 12 weeks, conducted in Asian regions, were parallel-designed, involved obese or overweight participants and participants with type 2 diabetes mellitus (T2DM) or cardiovascular diseases, used tea catechins, and used a dietary supplement intervention. A significantly negative effect on leptin levels was observed in studies conducted in Asian countries, with healthy participants and participants with T2DM, used whole food interventions, and involved participants with lower baseline leptin levels. In conclusion, flavonoid intake significantly increased circulating adiponectin and decreased leptin levels; however, study heterogeneity was very high.Future well-designed trials are required to address heterogeneous study designs and clarify the efficacy of plants in regulating adiponectin and leptin levels.

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Effect of Steamed Onion (ONIRO) Consumption on Body Fat and Metabolic Profiles in Overweight Subjects: A 12-Week Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Cited by 11 publications

References 36 publications

Effect of onion on blood lipid profile: A meta‐analysis of randomized controlled trials

Effect of onion on blood lipid profile: A meta‐analysis of randomized controlled trials

Antiobesity effects of onion (Allium cepa) in subjects with obesity: Systematic review and meta‐analysis

Effect of flavonoid intake on circulating levels of adiponectin and leptin: A systematic review and meta‐analysis of randomized controlled clinical trials

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