Effect of Streptokinase on Reperfusion After Acute Myocardial Infarction and Its Complications: An Ex-Post Facto Study

Abstract

Introduction:Emergency treatment of patients with acute myocardial infarction is very important. Streptokinase in Iran is often as the only clot-busting medication is used. The purpose of using streptokinase medication is to revive the ischemic heart tissue, although has dangerous complications too. Therefore, the present study aimed to determine the effect of streptokinase on reperfusion after acute myocardial infarction and its complications, has been designed and conducted.Materials and Methods:This is an Ex-post facto study. The study population included patients who suffer from acute myocardial infarction. The sample size was 300 patients, and 2 groups were matched, in variables of age, sex, underlying disease, frequencies and area of MI.Data collection did by researcher making questionnaire, that accept face and content validity by 10 expert researcher, the reliability was conducted with Spearman’s test (r=0.85) by Test-retest method. Data analysis did by SPSS software: V 12.Findings:Mean of EF in SK group was (46.15±8.11) and in control group was (43.11±12.57). Significant relationship was seen between SK, arrhythmia occurring and improve EF reperfusion by chi-square test (p=0.028), (p=0.020). The most arrhythmia in SK group was Ventricular Tachycardia (20.7%). Significant statistical relation between SK and mortality were found by Chi-square test (p=0.001). But a meaningful statistical relation was not found between SK and pulmonary edema incidence (p=0.071).Conclusions:Nurses of CCU should be aware about SK complications such as hypotension, bleeding and arrhythmias. Proposed compare SK and tissue plasminogen drug in reperfusion and complications effect.

Comparison of in-hospital outcome of patients of myocardial infarction with and without streptokinase reperfusion therapy.

“…76.0% male with male to female ratio of 3.1:1. Similar to our study, male dominance was also observed in a study by Taheri L et al 13 , i.e. 61.67%.…”

“…In our study, 3.33% and 5.83% patients were reported with VT/VF in SK and non SK groups (p=0.297), respectively and overall frequency of VT/VF was 4.34%. However, higher VF rate was reported in a study by Taheri L et al 13 , i.e. 8.7% and 5.3% in SK and non SK groups, respectively.…”

“…36.67%. Similarly, in a study by Taheri L et al 13 , commonest co-morbidity was hypertension (14.7%), followed by heart ischemia (11.3%), diabetes (8.7%) and hyperlipidemia (1.0%). However, in a study by Uddin F and Hoque FAK 14 , the most common comorbidity was diabetes mellitus (40.6%) followed by hypertension (37.1%).In our study, 35.0% patients were smoker.…”

“…Atrial fibrillation was 0.55% and 1.67% in SK and non SK groups (p=0.343) respectively and overall frequency of atrial fibrillation was 1.0% in our study. In a study by Taheri L et al 13 , atrial fibrillation was 2.7% and 2.7% in SK and non SK groups, respectively. However, overall lower atrial fibrillation frequency i.e.…”

Acute care for the three leading causes of mortality in lower-middle-income countries: A systematic review

“…The next level of treatment is systemic thrombolysis with streptokinase or tissue plasminogen activator (TPA); these medications can reduce mortality in LMIC. [ 24 26 27 ] Interventional approaches such as PCI with balloon angioplasty or stenting require greater infrastructure and more advanced practitioners. PCI was shown to have better outcomes than thrombolysis.…”