Effect of streptozotocin-induced diabetes on lipids metabolism in the salivary glands

Sphingolipids metabolism in the salivary glands of rats with obesity and streptozotocin induced diabetes

“…In this study, we have shown that streptozotocin induced diabetes leads to a decrement in phospholipids content which indicates subsequent atrophy and malfunction in both the parotid and salivary glands. Another interesting finding of the above‐cited study was the reported increase in triacylglycerol accumulation with respect to both the parotid and salivary glands of diabetic animals (Matczuk, Zalewska, Lukaszuk, Garbowska, et al, ). The aforementioned data strongly indicate that the parotid and submandibular salivary glands are characterized by different metabolic activities.…”

“…So far, the conducted analysis have encompassed amongst others: carbohydrate metabolism (Nicolau, de Matos, de Souza, Neves, & Lopes, ; Nogueira, Santos, & Nicolau, ), protein levels (Stewart et al, ), electrolytes (Lasisi & Fasanmade, ), oxidative damages (Knas, Maciejczyk, Daniszewska, et al, ; Knas, Maciejczyk, Sawicka, et al, ), or the presence of immunoglobulin (Metidieri et al, ; Malicka, Kaczmarek, & Skoskiewicz‐Malinowska, ). Remarkably, aside from our recent papers on this topic (Matczuk, Zalewska, Lukaszuk, Garbowska, et al, ; Matczuk, Zalewska, Lukaszuk, Knas, et al, ) scientific reports regarding salivary glands lipid composition are virtually non‐existent. This seems to be quite odd given the well‐established causative link between lipid over‐accumulation (e.g., diacylglycerols, triacylglycerols, and ceramides) and impaired tissue/organ functioning found in skeletal muscles (Kurek et al, ; Lukaszuk, Miklosz, Chabowski, & Gorski, ), liver (Chabowski et al, ; Konstantynowicz‐Nowicka, Harasim, Baranowski, & Chabowski, ), heart (Harasim et al, ), and adipose tissue (Matravadia, Zabielski, Chabowski, Mutch, & Holloway, ).…”

“…Interestingly, the abovementioned disturbances in lipid metabolism were observed mainly in the glycolytic submandibular salivary glands (Matczuk, Zalewska, Lukaszuk, Knas, et al, ). Furthermore, in another study of ours (Matczuk, Zalewska, Lukaszuk, Garbowska, et al, ) we determined lipid profile of the salivary glands of rats with streptozotocin induced diabetes. In this study, we have shown that streptozotocin induced diabetes leads to a decrement in phospholipids content which indicates subsequent atrophy and malfunction in both the parotid and salivary glands.…”

“…The aforementioned data strongly indicate that the parotid and submandibular salivary glands are characterized by different metabolic activities. Moreover, streptozotocin induced diabetes (an experimental model mimicking clinical type 1 diabetes) exerted slightly different effect(s) on salivary glands lipid metabolism in comparison with the type 2 prediabetic state induced by high fat diet feeding (Matczuk, Zalewska, Lukaszuk, Garbowska, et al, ; Matczuk, Zalewska, Lukaszuk, Knas, et al, ).…”

“…Moreover, these organs represent two different types of metabolism (oxidative—PSG, glycolityc—SMSG) (Ibuki, Simões, & Nogueira, ). This last notion seems to be quite important given a different response pattern observed for some tissues, for example, skeletal muscles (Kurek et al, ) and the salivary glands (Matczuk, Zalewska, Lukaszuk, Garbowska, et al, ; Matczuk, Zalewska, Lukaszuk, Knas, et al, ), in the case of (pre)diabetic animals.…”