Effect of stress, metyrapone and adrenalectomy on compensatory ovarian hypertrophy.

Yaginuma, Tsutomu; Kobayashi, Takuya

doi:10.1507/endocrj1954.24.403

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…It has been suggested that, in stress, ACTH production seems to be at the expense of gonadotrophins (Selye, 1951) and inhibition of pituitary gonadotrophin release by excessive amounts of ACTH has been reported by several investigators (Nowell & Chester Jones, 1957;Yaginuma & Kobayashi, 1977). It is therefore possible that the corticosterone treatment in the present experiments may be acting by decreasing ACTH secretion.…”

Section: Resultsmentioning

confidence: 57%

EFFECT OF CORTICOSTERONE ON SERUM CONCENTRATIONS OF α2u-GLOBULIN AND ON SPERMATOGENESIS IN OESTROGEN-TREATED RATS

Biswas¹,

Ghosh²,

Neuhaus³

1982

Journal of Endocrinology

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Treatment of adult male rats with oestradiol-17 beta (50 microgram/100 g body wt per day for 7 days) resulted 14 days later in reduced levels of alpha 2 micro-globulin in serum and inhibition of spermatogenesis. Administration of corticosterone (2 mg/day) for 14 days to oestrogen-treated rats raised the concentration of alpha 2 micro-globulin in the serum and prevented spermatogenic degeneration. It is concluded that endogenous alpha 2 micro-globulin induced by corticosterone may play a role in spermatogenesis in oestrogenized rats.

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Section: Resultsmentioning

confidence: 57%

EFFECT OF CORTICOSTERONE ON SERUM CONCENTRATIONS OF α2u-GLOBULIN AND ON SPERMATOGENESIS IN OESTROGEN-TREATED RATS

Biswas¹,

Ghosh²,

Neuhaus³

1982

Journal of Endocrinology

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“…Adrenal hypertrophy in estrogen-treated rats may result from an increased ACTH secretion in response to the blockage of corticosteroids synthesis (Colby and Kitay -1974). Several investigators reported that excess ACTH synthesis results at the expense of gonadotropins (Nowell and Chester Jones -1957;Yaginuma and Kobayashi -1977). Whether the rise of serum concentration of gonadotrophins in estrogen-treated rats after corticosterone treatment is due to decreased ACTH secretion is not clear from the present investigations.…”

Section: Discussionmentioning

confidence: 64%

Studies on the Effect of Corticosterone Treatment on Testicular Activity, Serum Concentration of Gonadotrophins, Testosterone and α2u-Globulin in Rats Pre-Treated with Estrogen

Ghosh

Biswas

2009

Andrologia

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Adult male rats were treated Hiith estradiol-170 (50 pg/100 g body wt./day) for 7 days. When the animals were killed 14 days later, the levels of serum gonadotrophins, testosterone and azu-Globulin as well as the weight of sex organs were reduced, testicular 170-hydroxysteroid dehydrogenase (1 70-HSD) activity was also suppressed; spermatogenesis was inhibited. Administration of corticosterone (2 mg/day) for 14 days to estrogentreated rats increased the concentration of gonadotrophins, testosterone and az u-globulin in the serum. The weight of accessory sex organs and spermatogenesis appeared to be normal while 170-HSD activity increased in estrogen-treated rats after treatment with corticosterone. It is concluded that corticosterone has an effect on testicular function by inducing a2 .-globulin and gonadotrophins in estrogen treated rats. Untersuchungen uber die Auswirkungen einer Corticosteroidbehandlung auf die Hodenaktivitat, die Gonadotropin-, Testosteron-und az u-Globulin-Konzentration im Serum von ostrogenbehandelten RattenZusammenfassung: Erwachsene mannliche Ratten wurden mit 170-Ostradiol (50pg/ 100 g K.G./Tag) iiber 7 Tage behandelt. Bei Totung der Tiere 14 Tage spater waren die Serumkonzentrationen der Gonadotropine, des Testosterons und des az ,-Globulins ebenso wie das Gewicht der Geschlechtsorgane reduziert wie auch die Aktivitat der testikularen 17&Hydroxy-Steroid-Dehydrogenase (1 7/.?-HSD) unterbunden war, Die Spermatogenese war unterdriickt. Die Gabe von Corticosteroid (2 mg/Tag) iiber 14 Tage steigerte bei den ostrogenbehandelten Ratten die Serumkonzentration der Gonadotropine, des Testosterons und des az .-Globulins. Das Gewicht der Geschlechtsorgane und die Spermatogenese erschienen normal wahrend die 1 70-HSD-Aktivitiit bei den ostrogenbehandelten Ratten nach Behandlung mit Corticosteroid anstieg. Es wird geschlossen, daB Corticosteroid eine Wirkung auf die Hodenfunktion iiber die Bildung des azuGlobulins und der Gonadotropine bei ostrogenbehandelten Ratten hat. Introduction parenchymal cells in the adult male rats (Roy andRoy Alpha-2u-globulin, a sexdependent urinary protein, is synthesized by the hepatic

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“…Recently, Yaginuma & Kobayashi (1977) reported that adrenalectomy abolished compensatory ovarian hypertrophy. The phenomenon of compensatory ovulation, a more sensitive and reliable indicator of the pituitary-ovarian relationship, was used in this study to test the neuroendocrine reflex arc.…”

Section: Discussionmentioning

confidence: 99%

Adrenalectomy Has a Differential Effect on the Ovarian Response of Two Strains of Rat

Jj¹,

Rd²

1980

Journal of Endocrinology

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Evidence indicates that the ovarian regulatory mechanism of different strains of rat may respond differently to adrenalectomy; this study examined that possibility. Adult female Sprague-Dawley and Holtzman rats were maintained under constant environmental. Adult female Sprague-Dawley and Holtzman rats were maintained under constant environmental conditions and each strain was divided into groups: intact; adrenalectomized; unilaterally ovariectomized; adrenalectomized and unilaterally ovariectomized for 30 days; adrenalectomized 30 days previously and then unilaterally ovariectomized followed by one oestrous cycle; adrenalectomized 30 days previously and then unilaterally ovariectomized followed by one oestrous cycle with progesterone treatment (2 mg); adrenalectomized 30 days previously and then unilaterally ovariectomized followed by one oestrous cycle with corticosterone treatment (2.5 mg/100 g). All operations and autopsies were performed at metoestrus. Chronically adrenalectomized rats shed fewer ova per ovary than intact animals. Rats that had been unilaterally ovariectomized or adrenalectomized and unilaterally ovariectomized for 30 days showed conpensatory ovulation as compared with intact rats and rats adrenalectomized for 30 days. Only the Sprague-Dawley rats that were adrenalectomized for 30 days and unilaterally ovariectomized for one oestrous cycle demonstrated compensatory ovulation. The remaining ovary in similarly treated Holtzman rats failed to compensate. Neither progesterone nor corticosterone influenced compensatory ovulation in the Sprague-Dawley rats, but both hormones caused an increase in the number of eggs ovulated in the Holtzman animals. In conclusion, the results of this study indicated that there is a strain-specific responsiveness of the ovary to adrenalectomy as assessed by compensatory ovulation.

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Effect of stress, metyrapone and adrenalectomy on compensatory ovarian hypertrophy.

Cited by 4 publications

References 16 publications

EFFECT OF CORTICOSTERONE ON SERUM CONCENTRATIONS OF α2u-GLOBULIN AND ON SPERMATOGENESIS IN OESTROGEN-TREATED RATS

EFFECT OF CORTICOSTERONE ON SERUM CONCENTRATIONS OF α2u-GLOBULIN AND ON SPERMATOGENESIS IN OESTROGEN-TREATED RATS

Studies on the Effect of Corticosterone Treatment on Testicular Activity, Serum Concentration of Gonadotrophins, Testosterone and α2u-Globulin in Rats Pre-Treated with Estrogen

Adrenalectomy Has a Differential Effect on the Ovarian Response of Two Strains of Rat

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