Effect of Strontium-Doped Bioactive Glass on Preventing Formation of Demineralized Lesion

Abstract

This study investigated the effect of strontium-doped bioactive glass (SBAG) on the formation of dental demineralized lesions. Materials and methods: The study materials were 48 sound human tooth specimens with both dentine and enamel, divided equally into four groups: Group 1 (SBAG), Group 2 (SBAG+Fluoride), Group 3 (Fluoride), and Group 4 (Water as control). After 14 days of pH cycling, the surface morphology of the specimens was observed by scanning electron microscopy. Crystal characteristics of the precipitates were assessed by X-ray diffraction (XRD). Micro-CT was used to measure the mineral loss and the depths of the demineralized lesions formed. Results: Exposure of collagen in inter-tubular areas in dentine was seen in the control group (Group 4) but not in Groups 1 to 3. In Group 2, there were obvious granular particles on the surface of the dentine. XRD revealed precipitation of apatites on the surface of the tooth specimens in Groups 1 to 3. The mean lesion depths in dentine were 81.80 μm, 30.68 μm, 39.04 μm, and 146.36 μm in Groups 1 to 4, respectively (p < 0.001). Lesions in enamel were only found in the control group. The mean mineral loss values in the dentine lesions were 1.25 g/cm3, 0.88 g/cm3, 0.87 g/cm3, and 1.65 g/cm3, in Groups 1 to 4, respectively (p < 0.001). Conclusion: Strontium-doped bioactive glass has a preventive effect on the formation of demineralized lesions in enamel and dentine.

Increased Fluorohydroxyapatite across Dentin after Fluoride Iontophoresis

“…Although the a-axis of the apatite lattice seemingly reduced after the CIP, this was not significant (P = 0.35; Table ). This is consistent with previous studies in nanoscale materials showing that crystal growth along the c-axis was significantly correlated with the degree of fluoride substitution into the HA (Mei et al 2017;Dai et al 2021). Correspondingly, the representative Raman spectra demonstrated a marked decrease and increase with a noticeable sharpening of the typical phosphate band after etching and CIP, respectively, while the v 1 CO 3 2− peaks were slightly changed compared with before treatment (Fig.…”

“…3E and F). Therefore, this evidence confirmed that CIP treatment enabled the F − substitution into the HA, becoming an FHA, which is in agreement with studies on synthesized HA showing that the increased FWHM and the shifted position of the v 1 PO 4 3− Raman peak are directly associated with an increasing compact and ordered apatite structure (Dai et al 2021).…”

Dynamics of Dental Enamel Surface Remineralization under the Action of Toothpastes with Substituted Hydroxyapatite and Birch Extract

“…Silicon was reported to have a role in the remineralization process of demineralized dentin and enamel following in vitro testing [37][38][39]. Lastly, the presence of strontium is reported to decrease the demineralization of enamel while also impeding the loss of surface hardness in more acidic environments [40,41].…”

Bioactive Glasses Containing Strontium or Magnesium Ions to Enhance the Biological Response in Bone Regeneration

“…Magnesium and strontium ions have been added to biodegradable structures for soft tissue regeneration, in enamel repair by inducing differentiation and proliferation of human dental pulp cells, as surface treatment of dental implants to improve the integration of gingival epithelial cells and fibroblasts, and have antibacterial effect for common periodontal pathogens. Some magnesium-based materials promote beneficial mechanical properties with elastic modulus similar to bone and on the other hand, the addition of strontium shows interesting results in the prevention of demineralized lesion formation and on prevention of artificial dentine caries if contained in toothpaste [28][29][30][31][32][33][34][35].…”