Effect of structure and composition of nickel(II) complexes with salicylidene Schiff base ligands on their DNA/protein interaction and cytotoxicity

Ni(ii) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines

“…The electrophoretic pattern suggests that changes in conformations of the plasmid were caused by the binding of 1, and retardation of the migration of DNA through the gel is observed for molecules which bind covalently to DNA. [93][94][95] Evaluation of anticancer activity Nickel hydrazone complexes have been extensively investigated for anticancer properties [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] but in general, the literature data deals with their activity described by IC 50 concentrations with data obtained by mean of colorimetric assays. Such methodology provides only the information on how the applied compound reduces number of viable cells in the treated population with regard to non-treated control for a specic time of incubation, therefore, calculated IC 50 value gives an indication on antiproliferative activity of investigated treatment, but not on how the treatment affected cell proliferation: by triggering apoptotic or necrotic cell death, due to prolongation of mitotic cycle with delayed population growth, or by induction of cell dormancy.…”

“…[12][13][14] Hydrazone complexes of Ni exhibit a wide spectrum of biological activity, 11 and a number of these complexes have shown higher anti-cancer activity than the drugs approved for treatment of certain types of cancer. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] Ni(II) ion has d 8 electronic conguration, same as Pt(II)the metal ion in, so far, all of the approved anti-cancer treatment drugs: cisplatin (CDDP), carboplatin, oxaliplatin, nedaplatin, and lobaplatin. 30 Unlike Pt(II), which only exhibits square-planar geometry (coordination number four), Ni(II) oen exhibits higher coordination numbers, offering greater variation in geometry.…”

Schiff Base Metal Complexes as Anticancer Agents

“…Nickel salicylidene Schiff base metal complex were synthesized and characterized by Li et al [49]. The coordination of nickel(II) ion by ONNO donor in a tetradendate manner have been confirmed by single crystal X-ray structure.…”

Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA–binding properties

“…Previously, we have synthesized a series of achiral Cu/Ni (II) and chiral Mn (Ⅳ) complexes in order to explore the potential of Schiff-base metal complexes as anticancer drugs [19,20]. Their interaction with DNA/BSA and anticancer activities were also investigated, some of which exhibit higher cytotoxicity against some cancerous cell lines.…”