Rescuers' ability to properly administer cardiopulmonary resuscitation (CPR) depends on their ability to learn, remember, and apply the necessary cognitive, behavioural, and psychomotor abilities. In order to provide HCPs with the knowledge and abilities needed to do CPR in circumstances where life is at risk, such as cardiac or respiratory arrest, the researcher used CPR training classes. The training sessions will also include lectures on the theories underlying as well as skill teaching sessions, and a final exam. This study used baseline data to show the improvement in effective training program quality and comprehension. Given guidelines on how to make it better and general guidelines for applying them across all hospitals in GS. The purpose of this study was to evaluate the effectiveness of a training program for healthcare professionals working in critical care units at governmental hospitals in the Gaza Strip. In order to assess the quality and knowledge of CPR among HCPs in these institutions, researchers employed a pre-post quasi-experimental design before and after education intervention studies (Al-Shifa). The training program's efficacy effect size was calculated using partial eta squared; the average score in the pre- and post-tests, paired t-test, P value, and MD with 95% CI were as follows: total score (0.360.10 vs 0.880.06, t = 43.05, P0.001, MD = 0.519, 95% CI =0.495-0.543), and effect size by Partial eta squared were 0.980. Specialists from all over the world who advice stakeholders on how to improve the standard of HCPs (Doctors and Nurses) offered in the ICU, ER, and CCU in the Gaza Strip are in a heated debate on CRP. Governmental hospitals with continuing education committees implement rigorous strategies to improve the knowledge and clinical proficiency of nurses and doctors, Urging HCPs to put in more effort and carry out more research in order to enhance the standard of their profession, save patients, and strengthen their areas of weakness in order to become more proficient and effective from a scientific and practical perspective (HCPs). Guidelines and suggestions were made to stakeholders that might improve the standard of CPR provided for critical care in ERs, ICUs, and CCUs.