Effect of subacute methyl parathion administration on the pharmacokinetics and pharmacodynamics of nifedipine in rats

Gelal, Ayşe; Eminoglu, Ozlem; Kaplan, Yusuf Cem; Kalkan, Şule

doi:10.1016/j.etap.2006.11.010

Cited by 1 publication

(1 citation statement)

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“…Nifedipine is rapidly and almost completely absorbed from the gastrointestinal tract, but undergoes an extensive first‐pass metabolism (Iwao and others 2002; Gelal and others 2007). Nifedipine is metabolized in the gut wall and liver into inactive metabolites mainly by CYP3A (Iwao and others 2002) and is a well‐established substrate of CYP3A.…”

Section: Resultsmentioning

confidence: 99%

Effect of Diallyl Trisulfide on the Pharmacokinetics of Nifedipine in Rats

Wang¹,

Zou²,

Zhao³

et al. 2011

Journal of Food Science

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This study aimed to evaluate the effect of diallyl trisulfide (DATS), a major component derived from garlic, on the pharmacokinetics of nifedipine. Pharmacokinetic parameters of nifedipine were determined in rats following an oral gavage (3 mg/kg) or intravenous administration (0.75 mg/kg) of nifedipine with co-administration of DATS (20 mg/kg) and long-term pretreatment of DATS (20 mg/kg/d for 15 consecutive days). Compared to the control groups, higher C(max) and AUC(0-24 h) were observed for oral gavage of nifedipine after short-term and long-term pretreatment of DATS, whereas those for intravenous nifedipine were little changed. The oral bioavailabilities of nifedipine were remarkably enhanced via the concomitant use of DATS. In conclusion, DATS increased the oral exposure of nifedipine in rats likely by the modification of intestinal metabolism of nifedipine, indicating that combined use of DATS or DATS-containing supplement with nifedipine may require caution because high plasma concentrations may lead to an undesired toxicity of this agent. Practical Application: Patients suffering from cardiovascular disease should take caution in combined use of DATS or DATS-rich garlic supplement with nifedipine because long-term treatment of DATS could lead high plasma concentrations of nifedipine.

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Section: Resultsmentioning

confidence: 99%