Effect of subchronic administration of ethanolic leaf extract of croton zambesicus on biochemical parameters of rats

Okokon, JE; Nyong, ME; Ettebong, Ette Okon

doi:10.4314/njnpm.v9i1.11836

Cited by 2 publications

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“…These metabolites have been reported in the literature as having different extents of antimalarial activity. 35–37 Many species of the genus Croton also reportedly have promising antimalarial activity in different in vitro and in vivo studies. 38 …”

Section: Discussionmentioning

confidence: 99%

In vivo antimalarial activity of the crude root and fruit extracts of Croton macrostachyus (Euphorbiaceae) against Plasmodium berghei in mice

Mekonnen

2015

Journal of Traditional and Complementary Medicine

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Euphorbiaceae (Croton macrostachyus H.; 巴豆 bā dòu) is used in Ethiopian folklore medicine for the treatment of malaria, gonorrhea, diabetes, wounds, fungal infections, and helminths. No scientific investigations have been performed to substantiate these claims. This study aimed to investigate the in vivo antiplasmodial activity of 80% methanol extract of the fruit and the root of Croton macrostachyus H. in a rodent model of malaria. The rodent malaria parasite Plasmodium berghei was used to inoculate healthy 8-week-old male Swiss albino mice weighing 23–27 g. Each of the hydroalcoholic crude extracts (200 mg/kg, 400 mg/kg, and 600 mg/kg) were administered to different groups of mice. The parameters of parasitemia, survival time, body weight, temperature, and packed cell volume were determined using Peter's test and Rane's test. Both extracts significantly inhibited parasitemia and increased survival time in infected mice. Maximum suppression and prolongation were obtained at the highest doses used in the study. The crude extracts prevented loss of weight and temperature, but did not affect the packed cell volume. This study suggests that the root and fruit extracts of the plant both have promising antiplasmodial activity against Plasmodium berghei in a dose-dependent manner, which supports the folkloric use of the plant for treating malaria.

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Section: Discussionmentioning

confidence: 99%

In vivo antimalarial activity of the crude root and fruit extracts of Croton macrostachyus (Euphorbiaceae) against Plasmodium berghei in mice

Mekonnen

2015

Journal of Traditional and Complementary Medicine

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“…Different studies have shown that antimalarial properties of medicinal plants have been associated with a single metabolite or a combination of its secondary metabolites such as terpenoids, flavonoids, alkaloids and phenolic compounds. These metabolites have been reported in different research as having antimalarial property [18][19][20]. The presences of these secondary metabolites in A. indica root extract are responsible for the plant antimalarial activity.…”

Section: Discussionmentioning

confidence: 96%

Experimental and Mathematical Model for the Antimalarial Activity of Methanolic Root Extract of Azadirachta indica (Dongoyaro) in Mice Infected with Plasmodium berghei NK65

Olaniyi

Oshiobugie

Raphael

2020

JAMCS

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The study determines the experimental and mathematical model for the anti-plasmodial activity of methanolic root extract of Azadirachta indica in Swiss mice infected with Plasmodium berghei NK65. Phytochemical analyses, antimalarial activity of the methanolic root extract of A. indica was determined in mice infected with Plasmodium berghei NK65 using standard procedure. Liver biomarker enzymes were also determined. The model P. berghei induced free and P. berghei infected equilibrium were determined. The stability of the model equilibrium points was rigorously analyzed. The phytochemicals present in the extract include: alkaloid, flavonoid, saponin and phenolic compounds etc. The experimental study consists of five groups of five mice each per group. Group A, B, C, D and E were healthy, infected without treatment, infected mice treated with fansidar (10 mg/kg), chloroquine (10 mg/kg) and 250 mg/kg body weight of A. indica methanolic root extract respectively. The extract showed anti-plasmodial activity of 73.96%. The result was significant when compared with group B mice, though it was lower than that exhibited by fansidar (88.91%) and chloroquine (92.18%) for suppressive test. There were significant decrease (P<0.05) in plasma AST and ALT levels in the treated infected mice compared to the infected untreated mice. The results of the model showed that the P.berghei induced free equilibrium is locally and globally asymptotically stable at threshold parameter, less than unity and unstable when is greater than unity. Numerical simulations were carried out to validate the analytic results which are in agreement with the experimental analysis of this work.

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Effect of subchronic administration of ethanolic leaf extract of croton zambesicus on biochemical parameters of rats

Cited by 2 publications

References 0 publications

In vivo antimalarial activity of the crude root and fruit extracts of Croton macrostachyus (Euphorbiaceae) against Plasmodium berghei in mice

In vivo antimalarial activity of the crude root and fruit extracts of Croton macrostachyus (Euphorbiaceae) against Plasmodium berghei in mice

Experimental and Mathematical Model for the Antimalarial Activity of Methanolic Root Extract of Azadirachta indica (Dongoyaro) in Mice Infected with Plasmodium berghei NK65

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