Effect of substrate bias and substrate/plasma generator distance on properties of a-C:H:SiOx films synthesized by PACVD

Grenadyorov, A. S.; Solovyev, A. A.; Оскомов, К. В.; Работкин, С. В.; Elgin, Y.I.; Сыпченко, В. С.; Иванова, Н. М.

doi:10.1016/j.tsf.2018.11.005

Cited by 13 publications

(5 citation statements)

References 34 publications

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“…The interaction between implants and the bodily fluid is strongly influenced by their surface properties, which directly affect various postimplant biological reactions, including precipitation of different minerals, protein adsorption, cell adhesion, and proliferation [ 38 ]. Bociaga et al [ 39 ] report that the optimum silicon content for exerting a positive effect on medical and biological properties is 10–14 at.%. A silicon content in the coating higher than 20 at.%, results in chemical and structural changes, reducing its biocompatibility.…”

Section: Resultsmentioning

confidence: 99%

Endothelial Cell Behavior and Nitric Oxide Production on a-C:H:SiOx-Coated Ti-6Al-4V Substrate

Хлусов

Grenadyorov

Solovyev

et al. 2023

IJMS

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This paper focuses on the surface modification of the Ti-6Al-4V alloy substrate via a-C:H:SiOx coating deposition. Research results concern the a-C:H:SiOx coating structure, investigated using transmission electron microscopy and in vitro endothelization to study the coating. Based on the analysis of the atomic radial distribution function, a model is proposed for the atomic short-range order structure of the a-C:H:SiOx coating, and chemical bonds (C–O, C–C, Si–C, Si–O, and Si–Si) are identified. It is shown that the a-C:H:SiOx coating does not possess prolonged cytotoxicity in relation to EA.hy926 endothelial cells. In vitro investigations showed that the adhesion, cell number, and nitric oxide production by EA.hy926 endothelial cells on the a-C:H:SiOx-coated Ti-6Al-4V substrate are significantly lower than those on the uncoated surface. The findings suggest that the a-C:H:SiOx coating can reduce the risk of endothelial cell hyperproliferation on implants and medical devices, including mechanical prosthetic heart valves, endovascular stents, and mechanical circulatory support devices.

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Section: Resultsmentioning

confidence: 99%

Endothelial Cell Behavior and Nitric Oxide Production on a-C:H:SiOx-Coated Ti-6Al-4V Substrate

Хлусов

Grenadyorov

Solovyev

et al. 2023

IJMS

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“…The plasma-assisted chemical vapor deposition (PACVD) described in [28][29][30] was used to obtain a-C:H:SiO x films. The PACVD process was provided by the plasma generator with hot cathode.…”

Section: Preparation Of A-c:h:sio X Coatingsmentioning

confidence: 99%

“…Our previous research [28][29][30] reports on the effect from these parameters on different properties of the a-C:H:SiO x film. films can be provided through varying the deposition parameters such as process pressure, precursor consumption, discharge current, filament current, and substrate bias voltage.…”

Section: Preparation Of A-c:h:sio X Coatingsmentioning

confidence: 99%

“…films can be provided through varying the deposition parameters such as process pressure, precursor consumption, discharge current, filament current, and substrate bias voltage. Our previous research [28][29][30] reports on the effect from these parameters on different properties of the a-C:H:SiOx film. In our experiment, the a-C:H:SiOx film deposition is performed in optimum conditions, which provide the formation of hard, wear-resistant, and biocompatible coatings [31,32].…”

Section: Preparation Of A-c:h:sio X Coatingsmentioning

confidence: 99%

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In Vitro Biodegradation of a-C:H:SiOx Films on Ti-6Al-4V Alloy

et al. 2022

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This paper focuses mainly on the in vitro study of a five-week biodegradation of a-C:H:SiOx films of different thickness, obtained by plasma-assisted chemical vapor deposition onto Ti-6Al-4V alloy substrate using its pulsed bipolar biasing. In vitro immersion of a-C:H:SiOx films in a solution of 0.9% NaCl was used. It is shown how the a-C:H:SiOx film thickness (0.5–3 µm) affects the surface morphology, adhesive strength, and Na+ and Cl− precipitation on the film surface from the NaCl solution. With increasing film thickness, the roughness indices are reducing a little. The adhesive strength of the a-C:H:SiOx films to metal substrate corresponds to quality HF1 (0.5 µm in thickness) and HF2-HF3 (1.5–3 µm in thickness) of the Rockwell hardness test (VDI 3198) that defines strong interfacial adhesion and is usually applied in practice. The morphometric analysis of the film surface shows that on a-C:H:SiOx-coated Ti-6Al-4V alloy surface, the area occupied by the grains of sodium chloride is lower than on the uncoated surface. The reduction in the ion precipitation from 0.9% NaCl onto the film surface depended on the elemental composition of the surface layer conditioned by the thickness growth of the a-C:H:SiOx film. Based on the results of energy dispersive X-ray spectroscopy, the multiple regression equations are suggested to explain the effect of the elemental composition of the a-C:H:SiOx film on the decreased Na+ and Cl− precipitation. As a result, the a-C:H:SiOx films successfully combine good adhesion strength and rare ion precipitation and thus are rather promising for medical applications on cardiovascular stents and/or friction parts of heart pumps.

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“…Контрольными образцами служили титановые образцы без a-C:H:SiO x покрытия (пять образцов Т1). Нанесение пленки происходило на вакуумной ионно-плазменной установке с технологическими параметрами осаждения, подробно описанными в [8].…”

Section: материалы и методыunclassified

The study of platelet reaction on a-C:H:SiOx coatings obtained via plasma enhanced chemical vapor deposition with bipolar bias voltage

et al. 2020

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Цель. Изучить в эксперименте in vitro адгезию тромбоцитов к a-C:H:SiO x пленке на титане для оценки ее атромбогенного потенциала. Материалы и методы. Тонкие (менее 1 мкм) a-C:H:SiO x пленки наносили на титановые пластины марки ВТ-6 размером 10 × 10 мм 2 и толщиной 0,2 мм с помощью вакуумной ионно-плазменной установки с использованием импульсного биполярного смещения. Шероховатость поверхности оценивали согласно ГОСТ 2789-73 с помощью атомно-силового микроскопа. Исследуемые образцы культивировали при 37 °C в течение 30 мин в плазме крови человека, обогащенной тромбоцитами, подготавливали для сканирующей электронной микроскопии, после чего подсчитывали плотность распределения кровяных пластинок, адгезирующих к исследуемому покрытию. Результаты. При одинаковом индексе шероховатости исследуемых образцов a-C:H:SiO x пленка в 116 раз снижала (в сравнении с необработанным титаном) количество тромбоцитов на 1 мм 2 поверхности. Заключение. Формирование на поверхности титанового сплава ВТ-6 тонкой пленки состава a-C:H:SiO x методом плазмохимического осаждения с использованием импульсного биполярного смещения значительно снижает плотность распределения тромбоцитов в сравнении с необработанной металлической поверхностью. Полученные in vitro данные предполагают существенный атромбогенный потенциал данного вида покрытий на поверхности устройств, контактирующих с кровью. Ключевые слова: адгезия тромбоцитов человека, in vitro, углеродная поверхность, модифицированная оксидами кремния, сканирующая электронная микроскопия, атомно-силовая микроскопия. Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.

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Effect of substrate bias and substrate/plasma generator distance on properties of a-C:H:SiOx films synthesized by PACVD

Cited by 13 publications

References 34 publications

Endothelial Cell Behavior and Nitric Oxide Production on a-C:H:SiOx-Coated Ti-6Al-4V Substrate

Endothelial Cell Behavior and Nitric Oxide Production on a-C:H:SiOx-Coated Ti-6Al-4V Substrate

In Vitro Biodegradation of a-C:H:SiOx Films on Ti-6Al-4V Alloy

The study of platelet reaction on a-C:H:SiOx coatings obtained via plasma enhanced chemical vapor deposition with bipolar bias voltage

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