1998
DOI: 10.1080/003655298750026912
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Effect of Sucralfate on Gastric Mucosal Inflammatory Responses Induced byHelicobacter pyloriLipopolysaccharide

Abstract: Gastric mucosal inflammatory responses to H. pylori lipopolysaccharide are characterized by a massive enhancement of the proinflammatory cytokine TNF-alpha and epithelial cell apoptosis and repression of IL-4. Our data also show that sucralfate is capable of inducing expression of the regulatory cytokine IL-4 and the suppression of apoptotic events triggered in gastric mucosa by the increase in TNF-alpha that is elicited by H. pylori lipopolysaccharide.

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Cited by 13 publications
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“…Groups 2 to 6 were treated orally with different doses of MEAM dissolved in water (25, 50, 100, 250 and 500 mg per kg body weight) for 10 days after ulcer induction with HP-LPS. Group 7 rats, which served as reference control, were treated with Sucralfate (100 mgkg −1 dissolved in water and administered orally) for 10 days [ 37 ].…”
Section: Methodsmentioning
confidence: 99%
“…Groups 2 to 6 were treated orally with different doses of MEAM dissolved in water (25, 50, 100, 250 and 500 mg per kg body weight) for 10 days after ulcer induction with HP-LPS. Group 7 rats, which served as reference control, were treated with Sucralfate (100 mgkg −1 dissolved in water and administered orally) for 10 days [ 37 ].…”
Section: Methodsmentioning
confidence: 99%