A field experiment was conducted at Crop Research Farm, Department of Agronomy, SHUATS, Prayagraj, 211007, Uttar Pradesh, India during (kharif 2022) to study the effect of micronutrients and sulphur on growth and yield of sesame. The treatments consisted of two levels of zinc (10 kg/ha,5 kg/ha), two levels of boron (5 kg/ha, 2.5 kg/ha) and three levels of sulphur (30 kg/ha, 40 kg/ha, and 50 kg/ha) and one control plot was used (the micronutrients were applied through soil application). The experiment was laid out in the Randomized Block Design with ten treatments which are replicated thrice on the basis of, one year experiment. The result showed that growth parameters viz., Plant height (127.57 cm), Plant dry weight ( 17.47 g plant-1), the application of micronutrients also improve the Crop growth rate (7.94 g/m2/day), Relative growth rate (0.026 g/g/day), and the yield parameters viz., Number of capsules plant-1 (43.37) seeds pod-1 (49.40), test weight (3.40 g), stover yield (1.98 t ha-1), grain yield ( 1.103 t ha-1), Harvest index (23.01%) were recorded significantly higher with application of zinc(5 kg ha-1), boron(2.5 kg ha-1) in combination with sulphur (50 kg ha-1). Maximum highest Net return (₹ 56,226 ha-1), Gross return (₹ 86,364 ha-1), and benefit cost ratio (1.86) were also recorded with the treatment 9 i.e., zinc (5 kg ha-1), boron (2.5 kg ha-1) in combination with sulphur (50 kg ha-1).