“…Several other authors have observed a strong synergistic effect between pressure and other process variables, although it has not always been considered the most influential parameter in the treatment with HP-CO2 (Melo Silva et al, 2013;Soares et al, 2013;Berenhauser et al, 2017;Michelino et al, 2018). As shown in Tables 2 and 3, this happened for treatments with pure HP-CO2 or with additives (Rao et al, 2016;Torabian et al, 2018), in the treatment either enzymes (e.g., polifenol oxidase, pectinmethylesterase and polygalacturonase) or microorganisms (e.g., Escherichia coli, Staphylococcus aureus and Bacillus subitilis spores), in solid (Bourdoux et al, 2022;Zhang et al, 2021;Barbosa et al, 2020;Feng et al, 2022) or non-solid matrices (Manzocco et al, 2017;Murtaza et al, 2019;Kincal et al, 2006;Benito-Román at al., 2019;Fleury et al, 2018;Illera et al, 2018;Marszałek et al, 2019;Yang et al, 2022).…”