1992
DOI: 10.1001/archsurg.1992.01420110063013
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Effect of Supplemental Dietary Glutamine on Methotrexate Concentrations in Tumors

Abstract: \ s=b\ This study evaluated the effects of supplemental dietary glutamine (GLN)

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Cited by 32 publications
(21 citation statements)
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“…Oral glutamine supplementation enhanced the effectiveness of chemotherapy against rhabdomyosarcoma and reduced chemotherapy-associated toxicity in a rat methotrexate model. 26,27 The significance of glutamine in tumor growth in malignant cell lines and animal models has been reviewed extensively by Souba. 28 Thus, it would appear that the augmentation of tumor growth by glutamine is counterbalanced by support of host glutamine stores, glutathione production, and increased immune function, particularly natural killer cell (NK) activity.…”
Section: Discussionmentioning
confidence: 99%
“…Oral glutamine supplementation enhanced the effectiveness of chemotherapy against rhabdomyosarcoma and reduced chemotherapy-associated toxicity in a rat methotrexate model. 26,27 The significance of glutamine in tumor growth in malignant cell lines and animal models has been reviewed extensively by Souba. 28 Thus, it would appear that the augmentation of tumor growth by glutamine is counterbalanced by support of host glutamine stores, glutathione production, and increased immune function, particularly natural killer cell (NK) activity.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies in our laboratory indicated that GLN supplementation stimulated the host GSH production, accompanied by decreased intratumoral GSH levels in an implantable sarcoma model [6,20,21]. Further studies with DMBAinduced breast cancer have shown that GLN supplementation reduced tumor growth and reversed the depressed GSH levels in normal tissue [22,23].…”
Section: Introductionmentioning
confidence: 96%
“…Biochemical analysis, in vitro and in vivo, animal and human studies along with phase I-phase II human clinical trials with pilot phase III clinical trials have shown that oral GLN is a safe and effective strategy to prevent and treat mucositis, stomatitis and cachexia [2][3][4][5][6]8,11,12,[15][16][17][18][20][21][22]25,26,[29][30][31][32][33][34]38,39 (M. M. Schubert, unpublished data, 2004). Concerns about GLN being preferentially used by the cancer cells, giving a tumorprotective effect, have been addressed in the research.…”
Section: Resultsmentioning
confidence: 99%
“…4,9,[20][21][22] This ability to evade chemoresistance is a very important finding to add to the strategies of integrative oncology.…”
Section: Resultsmentioning
confidence: 99%
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