Effect of supplementation of Rhodomyrtus tomentosa fruit juice in preventing hypercholesterolemia and atherosclerosis development in rats fed with high fat high cholesterol diet

Sinaga, Ernawati; Suprihatin, - -; Yenisbar,; Iswahyudi, Mardian; Setyowati, Sarwi; Prasasty, Vivitri Dewi

doi:10.1016/j.biopha.2021.111996

Cited by 16 publications

(9 citation statements)

References 36 publications

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“… 36 , 37 In the current study, rats fed on HFD showed an increase in body weight and high levels of plasma TC, TGs, LDL, and oxidative damage to tissues of the aorta, as already reported in previous studies. 38 - 40 Hypercholesterolemia causes an increase in free radical generation and change in lipid peroxide levels. It also promotes oxidative stress, which leads to higher amounts of oxidized LDL.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Caralluma edulis for its Potential Against Obesity, Atherosclerosis and Hypertension

et al. 2023

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Obesity, a chronic metabolic condition, is an increase in fat mass and blood lipid levels mainly causing atherosclerosis and hypertension, which further lead to cardiovascular complications. The objective of the study was to investigate the crude extract of Caralluma edulis (CE.Cr) for its potential against high-fat diet (HFD)-induced obesity and its related complications. Hyperlipidemia was induced in Wistar albino rats with HFD (1% cholesterol + 0.5% cholic acid) for 28 days. Treatment groups were administered with different doses of CE.Cr (100, 300 and 500 mg/Kg, p.o.) and the standard group received atorvastatin. At the end of study, sera were analyzed for biochemical markers and the aorta was dissected for microscopic examination. Antioxidant potential was evaluated and high-performance liquid chromatography (HPLC) analysis was performed. The hypotensive potential of CE.Cr was evaluated through an invasive technique. HPLC analysis of CE.Cr showed the presence of chlorogenic acid, caffeic acid, apigenin and naringenin. Histological examination of the aorta section showed anti-atherosclerotic effects which were also evident from decrease in serum total cholesterol, triglycerides and low-density lipoproteins levels. CE.Cr decreased mean arterial blood pressure and evoked significant hypotensive effects. The crude extract of C. edulis showed anti-obesity, antihypertensive, anti-atherosclerotic and antioxidant potential.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Caralluma edulis for its Potential Against Obesity, Atherosclerosis and Hypertension

et al. 2023

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“…The plant and fruits were identified at Herbarium Bogoriense, Center for Biology Research, Bogor, Indonesia. The preparation of the fruit juice followed the work of Sinaga et al (2021). The juice was made by processing the mesocarp of the fruits with slow-juicer.…”

Section: Preparation Of Fruit Juicementioning

confidence: 99%

Total Phenolic and Total Flavonoid Content, Antioxidant Activity, and Nutritional Profile of Ziziphus mauritiana Fruit Juice

Adilah

Saleh

Az-Zahra

et al. 2023

IJBPCS

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Ziziphus mauritiana is a plant species belonging to the Rhamnaceae family. It is commonly found in tropical and subtropical regions of Asia, and in Indonesia, this plant grows wild and thrives on the islands of Bali, Lombok and Sumbawa. The fruits of Z. mauritiana are edible, however, in Indonesia, it is underutilized and has very low economic value. To evaluate its possibility to be developed as a functional food, this study was conducted to determine the total phenolics and flavonoids, dietary fiber, and nutrients contained in the fruit juice of Ziziphus mauritiana. Total phenols and flavonoids contents were determined using Folin Ciocalteu and AlCl3 methods, respectively. The in vitro antioxidant activity of the juice was evaluated using the DPPH method. The content of soluble and insoluble dietary fiber was determined using the standard AOAC analysis method, and proximates analysis was conducted in accordance with SNI 01-2891-1992. The results of this study revealed that freeze-dried juice of Z. mauritiana fruit has total phenols content of 1690 mg GAE/100g, total flavonoids of 15.10 mg QE/100g, soluble dietary fiber of 0.61%, and insoluble dietary fiber 2.03%. However, the antioxidant activity of Ziziphus mauritiana fruit juice was weak with IC50 328.54 ppm. The proximate analysis revealed the crude fiber in the freeze-dried fruit juice was 0.56%, carbohydrates 82.43%, protein 3.34%, fats 0.31%, ash 3.62%, and water 10.30%. In conclusion, Ziziphus mauritiana fruit juice has a high content of total phenolic substances, high dietary fiber, and high nutritional value, therefore it has a good potential to be developed as a functional food.

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“…For example, Sinaga et al [55] supplemented the diet of male Sprague-Dawley rats fed a high-fat, high-cholesterol chow with Rhodomyrtus tomentosa fruit juice, rich in anthocyanins and other flavonoids. The fruit juice consumption prevented the increase of TAG, TC and LDL and avoided plaque build-up in blood vessels and the deposition of foam cells in the tunica intima of the aorta and coronary arteries.…”

Section: Low-grade Inflammation and Oxidative Cascades: The Links To ...mentioning

confidence: 99%

Functional foods to counterbalance low-grade inflammation and oxidative stress in cardiovascular diseases: a multilayered strategy combining food and health sciences

Granato

2022

Current Opinion in Food Science

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Effect of supplementation of Rhodomyrtus tomentosa fruit juice in preventing hypercholesterolemia and atherosclerosis development in rats fed with high fat high cholesterol diet

Cited by 16 publications

References 36 publications

Evaluation of Caralluma edulis for its Potential Against Obesity, Atherosclerosis and Hypertension

Evaluation of Caralluma edulis for its Potential Against Obesity, Atherosclerosis and Hypertension

Total Phenolic and Total Flavonoid Content, Antioxidant Activity, and Nutritional Profile of Ziziphus mauritiana Fruit Juice

Functional foods to counterbalance low-grade inflammation and oxidative stress in cardiovascular diseases: a multilayered strategy combining food and health sciences

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