Effect of Surface Morphology of Poly(ϵ‐caprolactone) Scaffolds on Adipose Stem Cell Adhesion and Proliferation

Diban, Nazely; Haimi, Suvi; Bolhuis-Versteeg, Lydia A.M.; Teixeira, Sérgio; Miettinen, Susanna; Poot, Andreas A.; Grijpma, Dirk W.; Stamatialis, Dimitrios

doi:10.1002/masy.201300106

Cited by 6 publications

(1 citation statement)

References 25 publications

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“…In contrast, PLGA-PVA membranes containing lower PVA concentrations did not present any water flux. The PCL hollow fibre membranes to be used as small blood vessel scaffolds exhibited hydraulic permeances between 200 and 800 L m -2 h -1 bar -1 depending on the coagulation bath employed (IPA or water) during their fabrication by phase inversion [42].…”

Section: Membrane Fluxmentioning

confidence: 99%

Facile fabrication of poly(ε-caprolactone)/graphene oxide membranes for bioreactors in tissue engineering

Diban

Sánchez-González

Lázaro-Díez

et al. 2017

Journal of Membrane Science

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Promising polymer membranes of blended biocompatible poly(ε-caprolactone) and graphene oxide (PCL/GO) and PCL and partially reduced graphene oxide (PCL/rGO) with outstanding water and nutrient transport properties for cell culture bioreactors were prepared using phase inversion at mild temperatures. Some of the prepared PCL/GO membranes were subjected to a 'chemical-free' GO post-reductive process using UV (PCL/GO/UV) irradiation. The PCL/rGO membranes exhibited 2.5 times higher flux than previously reported biocompatible polymer membranes for cell culture bioreactors, which was attributed to the highly interconnected porosity. On the other hand, the formation of PCL-graphene oxide composites in the PCL/GO and PCL/GO/UV membranes was not conclusive according to spectroscopic analyses, thermal analyses and mechanical characterization, probably due to the low graphene oxide loading in the membranes (0.1%w/w). The presence of graphene oxide-based nanomaterials in the polymer matrix slightly reduced the mechanical properties of the PCL-graphene oxide membranes by limiting the polymer chain mobility in comparison to that of the plain 2 PCL membranes. However, their mechanical stability was sufficient for the applications pursued. Finally, the biocompatibility assay indicated that the incorporation of GO and rGO into the PCL matrix enhanced the uniform distribution and morphology of the glioblastoma cells on the surface of the PCL-graphene oxide membranes.

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Section: Membrane Fluxmentioning

confidence: 99%