Effect of surface pre-treatments on biocompatibility of magnesium

Lorenz, Carla; Brunner, J.; Kollmannsberger, Philip; Jaafar, Leila; Fabry, Ben; Virtanen, Sannakaisa

doi:10.1016/j.actbio.2009.04.018

Cited by 160 publications

(118 citation statements)

References 26 publications

(26 reference statements)

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“…Both the gas development and the alkalisation of the medium by the released hydroxide ions lead to an enhanced localised corrosion as well as to a reduced cell adhesion [85,94].…”

Section: Degradation Of Cardiovascular Implantsmentioning

confidence: 99%

Cardiovascular Applications of Magnesium Alloys

Schilling¹,

Bauer²,

LaLonde³

et al. 2017

Magnesium Alloys

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Therapy in cardiovascular medicine often relies on implantation of prosthetic materials or application of stents. The diseases of many cardiovascular structures require their complete and immediate repair by utilising prosthetic materials. The ideal cardiovascular prosthesis involves good functional properties, capability of regeneration and does not activate the host's immune system. Ideally, the graft can be applied for a temporary use and degrades after a predefined period according to controlled degradation kinetics. Only biological grafts would provide this spectrum of properties by today's level of knowledge. However, biological prostheses exhibit some relevant drawbacks as well, such as insufficient mechanical stability or restricted availability. Implants or supporting structures of magnesium alloys would bridge this gap and would either provide a substrate for innovative and temporary grafts or would-as supporting structures-transiently add some missing properties to regenerative biological prostheses. This chapter reviews the different fields of cardiovascular therapeutic applications of magnesium alloys. The required properties of magnesium alloys and their preparation, fabrication and testing will be discussed under the specific cardiovascular perspective.

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“…Both the gas development and the alkalisation of the medium by the released hydroxide ions lead to an enhanced localised corrosion as well as to a reduced cell adhesion [85,94].…”

Section: Degradation Of Cardiovascular Implantsmentioning

confidence: 99%

Cardiovascular Applications of Magnesium Alloys

Schilling¹,

Bauer²,

LaLonde³

et al. 2017

Magnesium Alloys

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“…Surface modification is one of the methods to improve the corrosion resistance. [9][10][11][12][13][14][15][16][17][18][19] Especially, coatings with hydroxyapatite (HAp) and its related calcium phosphate compounds attract attention [11][12][13][14][15][16][17][18][19] because HAp is an essential element of bone and the calcium phosphate compounds precipitated from simulated body fluids improved the corrosion resistance of magnesium. 9,[20][21][22] A single-step process using aqueous solutions consisting of non-toxic compounds is desirable for the formation of HAp coating from the viewpoint of biocompatibility, production cost and environmental load.…”

Section: Introductionmentioning

confidence: 99%

Corrosion Behavior of Magnesium with Hydroxyapatite Coatings Formed by Hydrothermal Treatment

Hiromoto

Tomozawa

2010

Mater. Trans.

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Corrosion resistance of magnesium alloys must be improved for their applications to orthopaedic bioabsorbable devices. Since hydroxyapatite (HAp) is chemically stable in the body and is the main component of bones, HAp coatings have been well studied to improve the corrosion resistance and osteoconductivity of magnesium alloys. In this study, highly crystallized HAp coatings were formed on pure magnesium with a single-step hydrothermal treatment using a C 10 H 12 CaN 2 Na 2 O 8 solution with various pH values. Morphology of the HAp coating varied depending on the pH value. Corrosion behavior of the HAp-coated magnesium was investigated by anodic polarization, impedance and immersion tests in a simulated body fluid. It was revealed that the corrosion resistance of pure magnesium was improved more than 10 times with the HAp coatings. Stable localized corrosion was prevented with the HAp coatings although the occurrence and moderation of unstable localized corrosion appeared to take place at the defects of the HAp coatings. The initial protectiveness of the HAp coating depended on the treatment condition. During 4-day immersion, the precipitated HAp sealed the defects of the HAp coatings, resulting in the negligible release of magnesium ions regardless of the treatment conditions.

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“…In this sense, several articles have been published about cytotoxic effects of some Mg-alloying elements such as aluminum, zinc, and manganese [21][22][23], and others related to Mgalloy corrosion products. [24][25][26] It is well known that mechanical properties of Mg alloys may be improved by the addition of rare earth (RE) elements. This improvement has generally been associated to the formation of metastable RE-containing phases along the grain boundaries.…”

Section: Introductionmentioning

confidence: 99%