Effect of surface treatments/coatings and soft bake profile on surface uniformity and adhesion of SU-8 on a glass substrate

Grist, Samantha M.; Patel, Jasbir N.; Haq, Moeed; Gray, Bonnie L.; Kaminska, Bożena

doi:10.1117/12.842957

Cited by 4 publications

(1 citation statement)

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“…Cells in traps featuring Cr adhesion layers did not survive, but remained viable in all other traps. Fortunately, we have also shown that SU-8 adheres more strongly to Ti than Cr [30].…”

Section: Testing Of Fabricated Hydrodynamic Cell Trap Arraysmentioning

confidence: 59%

The Microfluidic Trapping of Antibody-Secreting Cells

Romanuik

Grist

Haq

et al. 2010

ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels: Parts a and B

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Therapeutic antibodies (Abs) are a rapidly growing and economically promising biotechnological research area. Therapeutic Ab production typically involves screening large numbers of Ab-secreting cells (ASCs) in order to identify those producing Abs targeting a specific antigen (Ag) with the highest affinity; a process often requiring weeks to complete. We are contributing to a multidisciplinary project focused upon the development of an immunobiosensing array ultimately intended to directly monitor the Ag-specific Ab production by thousands of ASCs on a single slide in real-time. Each ASC shall be microfluidically guided and trapped near a surface plasmon (SP) resonant nanohole array sensor so as to detect the binding of secreted Abs to Ag immobilized onto the sensor’s surface. This paper presents the initial progress of our contribution to this project: the development of polymeric microfluidic devices to guide and trap large ASC populations within arrays of single-cell traps. More specifically, this paper presents several different polymer-based microfluidic trapping devices, based upon perfusive flow-through cell traps and microwells which trap settling cells, which have been evaluated using COMSOL® simulations and tested using microsphere- and cell-based flow experiments. Our initial results are promising, and verify the functionality of our microfluidic cell trap designs.

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“…Cells in traps featuring Cr adhesion layers did not survive, but remained viable in all other traps. Fortunately, we have also shown that SU-8 adheres more strongly to Ti than Cr [30].…”

Section: Testing Of Fabricated Hydrodynamic Cell Trap Arraysmentioning

confidence: 59%

The Microfluidic Trapping of Antibody-Secreting Cells

Romanuik

Grist

Haq

et al. 2010

ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels: Parts a and B

Self Cite

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Nanotransfer Printed Dual-Layer Metasurfaces for Infrared Cut-off Applications

Yeh,

Hung,

Chung

et al. 2024

ACS Appl. Nano Mater.

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This study presents the design and fabrication of a vertically stacked aluminum (Al) nanosquare metasurface for infrared cutoff (IR-cut) applications, utilizing advanced nanomaterials to enhance device performance by blocking infrared light while maintaining transparency in the visible spectrum. Rigorous coupled wave analysis simulations were employed to evaluate and optimize the optical performance of the metasurface, focusing on key parameters such as nanosquare size, period, thickness, and the gap between stacked layers. The optimized metasurface design, based on simulation results, exhibited a balanced performance, achieving an average visible light transmittance of 59.9% across the 400−700 nm wavelength range, while providing effective extendedrange IR suppression with an average transmittance of only 6.5% in the 720−1200 nm range. To fabricate these metasurfaces, a nanotransfer printing (nTP) technique was employed, offering a simplified and efficient alternative to traditional lithography and liftoff processes. This design not only reduces the overall thickness of the optical devices but also facilitates easy integration into integrated optical components. This study highlights the potential of nTP-fabricated metasurfaces as effective and scalable solutions for IR-cut filters, advancing the field of applied nanomaterials while contributing to the development of more compact and efficient optical systems.

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