Effect of sweet grass extract against oxidative stress in rat liver and serum

Łuczaj, Wojciech; Stankiewicz-Kranc, Anna; Milewska, E.; Roszkowska-Jakimiec, W; Skrzydlewska, Elżbieta

doi:10.1016/j.fct.2011.09.014

Cited by 10 publications

(4 citation statements)

References 51 publications

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“…Due to its easy diffusion through biological membranes, lipid peroxidation products are responsible for most of the pathologies related to oxidative stress. Although the adverse effects of ethanol are produced in the liver, various other tissues are also affected, but to a lesser and variable degree [2] , [4] , [5] .…”

Section: Introductionmentioning

confidence: 99%

Xanthohumol, a prenylated flavonoid from hops ( Humulus lupulus L.), protects rat tissues against oxidative damage after acute ethanol administration

et al. 2014

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Ethanol-mediated free radical generation is directly involved in alcoholic liver disease. In addition, chronic alcohol bingeing also induces pathological changes and dysfunction in multi-organs. In the present study, the protective effect of xanthohumol (XN) on ethanol-induced damage was evaluated by determining antioxidative parameters and stress oxidative markers in liver, kidney, lung, heart and brain of rats. An acute treatment (4 g/kg b.w.) of ethanol resulted in the depletion of superoxide dismutase, catalase and glutathione S-transferase activities and reduced glutathione content. This effect was accompanied by the increased activity of tissue damage marker enzymes (glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and lactate dehydrogenase) and a significant increase in lipid peroxidation and hydrogen peroxide concentrations. Pre-treatment with XN protected rat tissues from ethanol-induced oxidative imbalance and partially mitigated the levels to nearly normal levels in all tissues checked. This effect was dose dependent, suggesting that XN reduces stress oxidative and protects rat tissues from alcohol-induced injury.

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Section: Introductionmentioning

confidence: 99%

Xanthohumol, a prenylated flavonoid from hops ( Humulus lupulus L.), protects rat tissues against oxidative damage after acute ethanol administration

et al. 2014

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“…The results have been promising [6][7][8]. In recent years, the importance of antioxidant activities of phytoconstituents has gained attention due to their capacity to act as powerful antioxidants.…”

Section: Introductionmentioning

confidence: 73%

Ethanol-Induced Alterations in Cardiac Enzymes–ameliorative Effect of Thespesia Populnea Leaf Extract

Rajbanshi¹,

Paranjape²,

Appanna

2017

Int J Pharm Pharm Sci

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Objective: This study covers the estimation of changes in cardiac enzymes such as ATPases and antioxidant enzymes following ethanoladministration in rats, and the possible ameliorative effect of leaf extract of the plant Thespesia populnea (TP) on these changes. Methods:Male adult Wistar rats were divided into 10 groups of six rats each. Vehicle controls received 5% gum acacia. Experimental groups received ethanol (20%, 2g/kg); or TP leaf extract (200 mg/kg and 400 mg/kg respectively); or vitamin E (25 mg/kg); or carvedilol (1 mg/kg) per orally every morning for 6 w, individually as well as in combination with ethanol. Following this, changes in the activities of Na + ATPase, Ca 2+ ATPase, Mg 2+ ATPase, and antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) were determined in the heart tissue and compared with those in vehicle control.Results: Ethanol (20%, 2g/kg) treatment caused a reduction from the vehicle control in activities of all the examined enzymes, with minimal reduction in Mg 2+ ATPase activity (29.26%) and maximal reduction in CAT activity (71.05%). With TP leaf extracts of 200 and 400 mg/kg, vitamin E and carvedilol individually, the vehicle controls showed percent changes in enzyme activities ranging from -8.24% for Mg 2+ ATPase activity to+109.39% for Na + ATPase activity caused by carvedilol. When administered along with ethanol, TP leaf extracts, vitamin E and carvedilol reversed the effect of ethanol to various degrees and brought back the enzyme activities to near vehicle control levels. While recovery with 200 mg Thespesia leaf extract was less, ranging from 24.1% for Mg 2+ ATPase activity to 190.91% for CAT activity, 400 mg Thespesia extract effected a greater recovery, with a minimum of 48.19% for Mg 2+ ATPase activity and a maximum of 222.73% for CAT activity, as compared with ethanol-treated rats as controls. These effects could be interpreted in terms of the adverse effects of ethanol on cardiac function and the ameliorative effects, primarily the antioxidant potential, of TP leaf extracts, vitamin E and carvedilol. Conclusion:The restoration of enzyme activities with TP leaf extract may promote recovery of cardiac tissue from oxidative damage. Results from the current study indicate that treatment with TP leaf extract reduces ethanol-induced oxidative stress in rat heart and hence may help prevent cardiac damage.

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“…Antioxidant activity of coumarins against the DPPH radical increases in the presence of an electron donating substituent, such as −OH, −CH 3 , −Cl, −OCH 3 [ 214 ] , while it decreases in the presence of a large substituent at the C-3 position due to the steric obstacle [ 215 ]. Coumarins also affect the activity of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase and S-glutathione transferase in the liver, kidney and plasma of rats [ 216 ]. Umbelliferone (7-Hydroxycoumarin) ( 10 ) ( Figure 2 ) and esculetin ( 8 ) increase the concentration of vitamins E and C, as well as GSH [ 217 ].…”

Section: Flavonoids Coumarins and Chromones As Anti-oxidative And Anti-inflammatory Agentsmentioning

confidence: 99%

Overview of the Antioxidant and Anti-Inflammatory Activities of Selected Plant Compounds and Their Metal Ions Complexes

et al. 2021

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Numerous plant compounds and their metal-ion complexes exert antioxidative, anti-inflammatory, anticancer, and other beneficial effects. This review highlights the different bioactivities of flavonoids, chromones, and coumarins and their metal-ions complexes due to different structural characteristics. In addition to insight into the most studied antioxidative properties of these compounds, the first part of the review provides a comprehensive overview of exogenous and endogenous sources of reactive oxygen and nitrogen species, oxidative stress-mediated damages of lipids and proteins, and on protective roles of antioxidant defense systems, including plant-derived antioxidants. Additionally, the review covers the anti-inflammatory and antimicrobial activities of flavonoids, chromones, coumarins and their metal-ion complexes which support its application in medicine, pharmacy, and cosmetology.

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Effect of sweet grass extract against oxidative stress in rat liver and serum

Cited by 10 publications

References 51 publications

Xanthohumol, a prenylated flavonoid from hops ( Humulus lupulus L.), protects rat tissues against oxidative damage after acute ethanol administration

Xanthohumol, a prenylated flavonoid from hops ( Humulus lupulus L.), protects rat tissues against oxidative damage after acute ethanol administration

Ethanol-Induced Alterations in Cardiac Enzymes–ameliorative Effect of Thespesia Populnea Leaf Extract

Overview of the Antioxidant and Anti-Inflammatory Activities of Selected Plant Compounds and Their Metal Ions Complexes

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