Effect of synbiotic supplementation in children and adolescents with cystic fibrosis: a randomized controlled clinical trial

Abstract

Synbiotic supplementation shown promise at diminishing the pro-inflammatory markers IL-6, IL-8 in the SCFG with positive bacteriology and NOx in the SCFG in children/adolescents with CF.

Systematic Review of Probiotics for Cystic Fibrosis Patients

“…The 9 studies included in this systematic review (Bruzzese et al, 2004 (16), Bruzzese et al, 2007 (17), Weiss et al, 2010 (18), Fallahi et al, 2013 (19), Del Campo et al, 2014 (20), Di Nardo et al, 2014 (21), Jafari et al, 2013 (22), Bruzzese et al, 2014 (23), Bruzzese et al, 2017(12), and de Freitas et al, 2017 (11)) are described in Table 1 part A. The study excluded from the analysis is also described in Table 1 part B: Infant Pina et al, 2008 (15).…”

“…Bruzzese et al (12) showed no significant clinical effects of a probiotic preparation in a prospective, randomized, placebo‐controlled study, with one of the largest samples of included patients (12). De Freitas et al (11) focused on inflammatory effects of a synbiotic preparation in children and adolescents with CF and found only mild effects in some of the inflammatory markers (11).…”

“…They advocated for new well-designed and adequately powered randomized controlled trials to confirm these findings; however, no suggestions were made regarding the design of this intervention. Two new studies were recently published (11,12) and were not included in previous reviews.…”

“…All included studies were considered to have a high risk of bias for the main measures according to the Cochrane Handbook criteria (13), as demonstrated in Figure 1; for this reason, a metaanalysis was not performed. Regarding treatment masking, 5 studies were randomized double-blinded trials (12,(19)(20)(21)23), while 1 study used a single-blind strategy (17), 2 were opened pilot studies (16,18), and 2 studies did not report blinding procedures (11,22).…”

Mês Nacional de Conscientização da Fibrose Cística no Brasil

“…Ministério da Saúde, 2017 A busca de artigos científicos foi realizada nas bases de dados PubMed e BVS por meio dos descritores "fibrose cística" ("cystic fibrosis") e "criança" ("child") combinados com "terapia nutricional" ("nutrition therapy"), "qualidade de vida" ("quality of life") ou "estado nutricional" ("nutritional status"), todos no idioma inglês e com seus respectivos sinônimos. (FREITAS et al, 2018).…”