Effect of Synbiotic Supplementation on Serum Systemic Inflammatory Marker and Serum Albumin in Patients Admitted to ICU

Abstract

Introduction: The role of inflammation and malnutrition in critically ill patients has been shown in some studies. The aim of the study is to determine the effect of symbiotic on serum systemic inflammatory marker (hs-CRP) and albumin in critically ill patients.Methods: Sixty patients admitted to the intensive care unit of Sabzevar Vasei hospital were randomized two groups that received symbiotic or placebo for 2 weeks. Levels of serum hs-CRP and albumin were measured before and after the study. Results:There was a significant differences between two groups the Levels of serum hs-CRP (P=0.0001) and albumin (P=0.0001). Conclusion:Results of study were showed that administration of symbiotic in critically ill patients reduced the levels of serum hs-CRP and increased the levels of serum albumin.

The Effect of Synbiotic and Probiotic Supplementation on Mental Health Parameters in Patients Undergoing Hemodialysis: A Double-blind, Randomized, Placebo-controlled Trial

“…[ 50 ] The mean Hb level showed a significant increasing trend in patients supplemented with probiotic or synbiotic formulations, while Hb level variability was observed in the placebo group. Considering the potential role of inflammation in CKD-anemia and Hb fluctuation,[ 47 48 ] the anti-inflammatory activity of probiotic strains observed in our previous studies[ 23 40 ] may explain these findings. In the study conducted by Fukushima et al .,[ 51 ] the serum Hb level of enterally fed elderly in-patients under probiotic treatment significantly improved which was also accompanied by a decrease in the inflammatory blood parameter, TNF-α (tumor necrosis factor-alpha).…”