Effect of Synertox® on broiler health and performance during aflatoxicosis

Abstract

Eighty, one-day-old commercial male broiler chicks (Ross 308), were distributed to four dietary treatments with two replicates of 10 chicks each, to study the effect of Synertox ® on broiler performance during aflatoxicosis. Birds were reared for 42 days. All birds were fed on diet with or without aflatoxin (AF) in feed, and with or without Synertox (ST) (enzymes, organic acids and yeast extract) in water. The treatments were as follow: T1 (0 ppm AF and no ST); T2 (2.5 ppm AF and no ST); T3 (0 ppm AF and 0.5 ml/l ST); T4 (2.5 ppm AF and 0.5 ml/l ST). Body weights and feed intake were recorded weekly. At 42 of bird's age, five birds were randomly selected for estimation of antibody titres against Newcastle disease (ND; for calculation of the relative weight of bursa of Fabricius, thymus and spleen as well as for scoring liver and kidney lesions. The results show that the total body weight gain through 42 days of rearing period that the gain was highest in T3. In the second order was the weight of the control group (T1), while in the third order was T4. The worst body weight gain was reported in T2, in which chicks fed AF. The same picture in body weight gain was obtained with feed consumption and feed conversion ratio. AF had a significant negative effect on the liver parenchyma of broiler chicks in treatment 2, by changing liver colour from mahogany to enlarged muddy or even to yellowish discolouration, with friable consistency with sub capsular haemorrhages. The addition of Synertox® was effective in restoring the normal red brown liver colour. Kidney were also affected by feeding AF (T2). They were enlarged, swollen and pale in colour. All lymphoid organs tested, thymus, bursa of Fabricius and spleen were negatively affected by feeding AF in broilers at 42 days of age. Synertox® was effective in counteracting the negative effect of AF on relative bursal weight, thymus and spleen relative weights. Aflatoxin had detrimental negative effect on the ND ELISA mean antibody titre. A significant restoring of ND antibody titre to those of control group (T1) was recorded by addition of Synertox® to the drinking water of broilers in (T4) compared with the AF fed T2 group. From the studied parameters it could be concluded that Synertox® could be used in counteracting the negative effects of AF on health and performance of broiler chicks.

Pharmacological effect of T-NilPlus® and Synertox®, commercial anti-mycotoxins, on broiler chickens in Egypt

“…The obtained results showed that birds treated with Synertox ® revealed no marked alterations in body weight and body weight gain also there were non-significant changes in feed conversion ratio FCR and higher feed consumption from 2 nd week to the end of the experiment. These results are in accordance with Shareef and Omar, (8) who reported that addition of Synertox ® in the drinking water showed a marked elevation in feed consumption with non-significant changes in FCR com-…”

“…This effect might be due to the potency of probiotic bacteria to induce chelate free radicals, capturing reactive oxygen species and inhibiting their cytotoxic activity Lin and Yen, (61) or due to the components that Synertox ® contains, that help in protein digestion. (8) The recorded data showed that chickens given T-Nil Plus ® evoked nonmarked alterations in serum levels of cholesterol, triglycerides, HDL and LDL. These results are in accordance with Zamanizadeh et al (62) ; Jazi et al, (63) and Sohail et al, (64) who reported that serum levels of cholesterol, triglycerides, HDL and LDL were not affected by Saccharomyces cerevisiae supplementation.…”

“…Ingredients (per 1000 mL): citric acid 80 mL, phosphorus acid 60 mL, malic acid 5 mL, tartaric acid 5 mL, disodium EDTA 15 mL, propylene glycol 100 mL, lactic acid 80 mL, calcium lactate 25 mL, dried bacillus subtilis fermentation extract 260 mL, sodium citrate 40 g, papain 40 g, distilled water (180 mL) up to 1000 mL. Dose: 0.5 mL per liter were administered according to Shareef and Omar (8) for 5 days.…”

“…(6) Most of the studies used Synertox ® as detoxifying agent in poultry feeds and reported the ability of it to compensate and supply the suffered chicks from aflatoxin with essential nutrients. (8) Probiotics are live microbial feed additives that beneficially improve the intestinal microbial balance of animal. (9) A wide range of microalgae, yeasts (Debaryomyces, Phaffia, and Saccharomyces), gram-positive bacteria (Bacillus, Carnobacterium, Enterococcus, Lactobacillus, Lactococcus, Micrococcus, Streptococcus, and Weissella) and gram-negative bacteria (Aeromonas, Alteromonas, Photorbodobacterium, Pseudomonas and Vibrio) have been applied as probiotics.…”

Study of Lactococcus lactis and Lactobacillus casei Probiotics Addition on Analysis of Laying Hens Strain Isa Brown Infected with E. coli

“…Penerimaan paling rendah berada diperlakuan kontrol infeksi, dikarenakan produksi telur per harinya yang rendah. Perihal tersebut sejalan pada penelitian sebelumnya yang menyampaikan bahwa dalam memberikan dosis probiotik melalui pakan unggas atau air minum adalah 0,1%-0,15% (Rowghani et al, 2007) atau dosis 2% untuk lebih optimal hasil (Shareef & Al-Dabbagh, 2009). Penelitian ini didukung oleh pendapat Lokapirnasari et al, (2019) yang menyatakan bahwa pemberian feed additives berupa probiotik Lactobacillus casei dan L. casei mampu digunakan sebagai alternatif AGP, sebab mampu menurunkan bobot telur dan hen-day production pada ayam petelur.…”