Effect of synthetic chicken and porcine vasoactive intestinal peptide on pancreatic blood flow in dogs

Inoue, Kazutomo; Suzuki, Takashi; Tobe, Takayoshi; Yajima, Haruaki

doi:10.1016/0143-4179(86)90014-4

Neuropeptides

1986

DOI: 10.1016/0143-4179(86)90014-4

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Effect of synthetic chicken and porcine vasoactive intestinal peptide on pancreatic blood flow in dogs

Kazutomo Inoue

Takashi Suzuki

Takayoshi Tobe

et al.

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1987

1994

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Cited by 3 publications

References 16 publications

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Vasoactive intestinal polypeptide increases whole pancreatic blood flow but does not affect islet blood flow in the rat

Jansson

1994

Acta Diabetol

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To evaluate the effects of vasoactive intestinal peptide (VIP) on whole pancreatic blood flow and islet blood flow in the rat, anaesthetized adult rats were injected intravenously for 90 s with VIP (500 ng/kg body weight). Immediately after the injection, the whole pancreatic and islet blood flows were measured with a microsphere technique. VIP markedly increased the former but did not affect the latter. Thus, the fraction of the whole pancreatic blood flow diverted through the islets was decreased. In separate experiments, the effects of VIP on the blood glucose and serum insulin concentrations of anaesthetized animals were investigated. VIP caused an acute increase (after 2 min) in the latter, but did not affect the former. It is concluded that VIP exerts its blood flow stimulatory properties only on the exocrine pancreas, and that it may increase the serum insulin concentrations without an associated change in islet blood perfusion.

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Vasoactive intestinal polypeptide increases whole pancreatic blood flow but does not affect islet blood flow in the rat

Jansson

1994

Acta Diabetol

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Microsphere Determination of Cochlear Blood Flow in Chickens

Zaluzec¹,

Ramzy²,

Wotring³

et al. 1987

Otolaryngol.--head neck surg.

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Chickens were injected with 9-micron-diameter radioactive microspheres. Cochleas were removed through the external auditory meatus, and the positions of all embedded microspheres were drawn under camera-lucida. Constant measurements of arterial pressures and postinjection blood-gas determinations confirmed that injections were made into normal circulatory systems. The averaged estimate of cochlear blood flow in chickens is 0.75 microliter/min. Variability in these data from chickens is similar to that reported from mammals. A potentially important but puzzling observation is an inverse relationship between blood flow to the cochlea and to the brain. The ease of cochlear extraction makes chickens ideal models for study of cochlear blood flow.

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Effect of Stimulation of Mucosal HCO‐ Secretion on Acid-Induced Injury to Porcine Duodenal Mucosa

Ainsworth

Fenger

Svendsen

et al. 1993

Scandinavian Journal of Gastroenterology

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The effect of stimulation of duodenal mucosal bicarbonate secretion with vasoactive intestinal peptide (VIP) on acid-induced damage to the duodenal mucosa was studied in anaesthetized pigs in which bile and pancreatic juice were diverted from the duodenum. Mucosal damage was quantitatively assessed histologically, and mucosal blood flow was determined by means of radioactively labelled microspheres. Compared with placebo, intravenous infusion of VIP (500 pmol/kg/h) significantly stimulated duodenal mucosal bicarbonate secretion (47 +/- 13 versus 249 +/- 53 mumol/h) without concomitant changes in mucosal blood flow (51.5 +/- 7.8 versus 48.5 +/- 9.1 ml/min/100 g) or arterial bicarbonate concentration (24.2 +/- 1.1 versus 23.4 +/- 0.9 mM). The same dose of VIP increased the acid disappearance rate in the duodenum (2.2 +/- 0.14 versus 3.3 +/- 0.09 mmol/h) and reduced the extent of damage to the duodenal surface (16 +/- 2% versus 7 +/- 2%) during duodenal infusion of 0.03 M HCl but not 0.1 M HCl. We conclude that the protection offered by VIP against the small dose of acid is most likely secondary to the effect of VIP on mucosal bicarbonate secretion. Thus, this study suggests that duodenal mucosal bicarbonate secretion, independent of mucosal blood flow, is an integral factor in duodenal mucosal defence.

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Effect of synthetic chicken and porcine vasoactive intestinal peptide on pancreatic blood flow in dogs

Cited by 3 publications

References 16 publications

Vasoactive intestinal polypeptide increases whole pancreatic blood flow but does not affect islet blood flow in the rat

Vasoactive intestinal polypeptide increases whole pancreatic blood flow but does not affect islet blood flow in the rat

Microsphere Determination of Cochlear Blood Flow in Chickens

Effect of Stimulation of Mucosal HCO‐ Secretion on Acid-Induced Injury to Porcine Duodenal Mucosa

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