Effect of systemic administration of silver nanoparticles in treatment of experimental periodontitis in albino rats

Abstract

Introduction: Periodontal disease is one of the main dental diseases that affect millions of people around the world. Modern nanotechnology progression and renovations through nanodentistry providing a suitable solution for the treatment of many dental illnesses including periodontal disease. Aim: Histological and ultrastructural evaluation of the effect of silver nanoparticles in treatment of periodontitis in albino rats. Materials and methods: A total of 18 adults male albino rats with body weight ranging from 150 to 180 gm were used and divided into three groups group 1: served as control, group 2: used for induction of experimental periodontitis using wiring around the cervix of mandibular central incisors for two weeks, and group 3: after induction of experimental periodontitis as in group 2 they were subjected to intraperitoneal injection with silver nanoparticles for the treatment of periodontitis three times per week for four weeks. Results: Histological and ultrastructural investigation revealed that periodontal ligament around ligated mandibular incisors showed marked improvement in the degenerated fibers after injection with silver nanoparticles in group 3 compared to group 2 as the fibers regained their association in strong bundles and they regained their attachment to regenerated bone and tooth surface. Conclusions: Marked regeneration of the periodontium of periodontally affected ligated mandibular incisors reflected that silver nanoparticles have a great anti-inflammatory effect

Impact of silver nanoparticle concentration in alginate microcapsules on their effects on morphological changes in periodontitis

“…Discussion. The results of our study demonstrated the development of degenerative inflammatory changes manifested by the presence of interstitial edema, along with destruction of bone tissue in the lower jaw in animals with experimental periodontitis, which was consistent with the published data [11]. However, in the course of our research, we established that these changes persisted for three weeks after removal of the ligature, which I implied their consistency.…”