Effect of systemic administration of beta-casomorphine-7 on nociception in rats

Дубынин, В. А.; Маклакова, А. С.; Nezavibat'ko, V. N.; Alfeeva, L. A.; Каменский, А. А.; Ашмарин, И. П.

doi:10.1007/bf00809564

Cited by 3 publications

(7 citation statements)

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“…The 5 mg/kg dose exerted similar but less marked effects, the only significant difference from the control group being a 100% increase in the ISLR (p<0.05). The inferior performance of the rats with regard to learning the active avoidance response cannot be accounted for by their reduced pain sensitivity since, as we found previously, the lowest analgesic dose of B-C-7 for rats is 10 mg/kg [1]. The dose of 20 mg/T,g did not cause significant changes in any of the parameters we measured to evaluate how this response was learned.…”

Section: Resultsmentioning

confidence: 83%

“…One of its typical members, the heptapeptide Tyr-Pro-Phe-Pro-Gly-Pro-Ile, dubbed 13-casomorphin-7 (B-C-7), has been shown capable of being absorbed into the blood [15] and acting on opiate ~t-and 5receptors [7]. It is logical to assume that 13-C-7 and its derivatives, like other opioid peptides, not only influence pain sensitivity and locomotion [1,2], but can also be involved in regulating the elaboration of various conditioned responses. Accordingly, we undertook the present study to test 13-C-7 and its analogs in various doses for their effects on the capacity of animals for learning.…”

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confidence: 99%

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Effects of β-casomorphin-7 on different types of learning in white rats

et al. 1995

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The heptapeptide [3-casomorphin-7, a casein fragment of cow's milk, accelerated the learning of a food-procuring habit in a T-maze by rats injected with this heptapeptide in a dose of 1 or 5 mg/kg body weight 5 min before the start of each learning session. This effect was blocked by pretreating rats with naloxone. On the other hand, [3casomorphin-7 in the indicated doses delayed learning of the active avoidance response involving the use of a painful reinforcing stimulus. The results of this study indicate that 13-casomorphin-7 attenuates defense reactions by shifting the total balance of motivations toward food-procuring behavior.

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Section: Resultsmentioning

confidence: 83%

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confidence: 99%

Effects of β-casomorphin-7 on different types of learning in white rats

et al. 1995

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“…All studies included at least 3154 animals in total (min 6 animals and max 639 animals per study; five studies did not report the exact number of animals included [18][19][20][21][22]). Most studies administered BCM-7 as injection [18][19][20][21][22][23][24][25][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] and ten studies administered it orally [25,[43][44][45][46][47][48][49][50][51]. Most studies provided BCM-7 alone, whereas three studies used a mix of BCM-fragments (including BCM-7) as intervention [25,44,50].…”

Section: Characteristics Of Studies Comparing Bcm-7 Vs Any Other Intervention(s)mentioning

confidence: 99%

“…Most studies compared this effect to other BCM fragments and investigated the opioid pathway for achieving the analgesic effect, including binding properties (e.g., affinity to opioid receptors). It was analysed in rats in five studies [18,23,[29][30][31], in cockroaches in one study [34] and in broiler chickens in one further study [20]. Results showed that BCM-7 achieved significant pain relief in animals receiving the intervention.…”

Section: Details Of Interventions and Health Outcomes In Studies Comparing Bcm-7 Vs Any Other Intervention(s)mentioning

confidence: 99%

A1- and A2 beta-casein on health-related outcomes: a scoping review of animal studies

et al. 2021

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Purpose Food-derived bioactive peptides may influence important physiological functions. An important example is beta-casomorphins, which are opioid peptides derived from A1 beta-casein in bovine milk and have been associated to be risk factors for non-communicable diseases in humans. A1 and A2 beta-casein are different with respect to the release of bioactive peptides, in particular BCM-7. However, evidence from human studies is limited and could be complemented with evidence derived from animal studies. We conducted a scoping review to identify animal studies investigating the effects of A1 beta-casein or BCM-7 compared to A2 beta-casein or any other intervention on health-related outcomes. Methods We systematically searched for relevant studies in two electronic databases (Medline, Embase; last search performed March 2020). Two reviewers independently undertook study selection and data extraction of included references. Results were summarized tabularly and narratively. Results We included 42 studies investigating various animal models, including rats, mice, rabbits, and dogs. Six studies investigated health-related outcomes of A1- vs. A2 milk, while most studies (n = 36) reported on physiological properties (e.g., analgesic effect) of BCM-7 as an opioid peptide. Included studies were extremely heterogeneous in terms of the study population, type of intervention and dose, and type of outcome measures. Conclusions Only a few studies comparing the effects of A1- and A2 milk were identified. More studies addressing this research question in animal models are needed to provide essential information to inform research gaps. Results from future studies could eventually complement research for humans, particularly when the body of evidence remains uncertain as is the case in the A1- and A2 milk debate.

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“…It has been shown that they influence nociception [1,2], regulate maternal and infant behavior [3], and possess anxiolytic [4] and cardiotropic actions [5]. However, the mechanisms through which these peptide bioregulators affect different physiological functions are still unclear.…”

Section: Introductionmentioning

confidence: 99%