Effect of T-2 toxin on in vivo lipid peroxidation and vitamin E status in mice

Vila, Berta Solano; Jaradat, Ziad W.; Marquardt, R. R.; Frohlich, A. A.

doi:10.1016/s0278-6915(01)00122-3

Cited by 57 publications

(29 citation statements)

References 25 publications

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“…Our results were similar to the report of Meki and Hussein (2001). However, some researchers showed that OTA and T-2 toxin significantly increased the content of thiobarbituric acid-reactive substances (TBARS) and MDA (Gautier et al, 2001;Vila et al, 2002). Therefore, mycotoxins may affect both sides of the antioxidant/pro-oxidant balance.…”

Section: Discussionsupporting

confidence: 88%

Protective effects of selenium and vitamin E on rats consuming maize naturally contaminated with mycotoxins

Chen

2009

Front. Agric. China

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Protective effects of antioxidant additives of selenium and vitamin E on rats that consumed maize naturally contaminated with mycotoxins were explored in this paper. Thirty-two Wistar female rats were randomly divided into four groups. The control group was given the basic diet with normal maize. The contaminated maize group was given the diet in which normal maize was replaced by mycotoxin-contaminated maize. The selenium group and vitamin E group were respectively fed mycotoxincontaminated diet supplemented with 0.4 mg$kg -1 selenium from yeast or 100 mg$kg -1 vitamin E. The trial lasted for 4 weeks. Compared with the control group, antioxidative status was decreased significantly in the contaminated maize group. However, the status in the selenium group and vitamin E group was increased significantly compared with the contaminated maize group. The activities of enzymes related to liver function were significantly higher in the contaminated maize group than those in the control group, whereas they were significantly lower in the selenium group and/or the vitamin E group compared to the contaminated maize group. It is concluded that selenium and vitamin E were able to alleviate oxidative stress and liver function damage due to the consumption of maize naturally contaminated with mycotoxins.

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Section: Discussionsupporting

confidence: 88%

Protective effects of selenium and vitamin E on rats consuming maize naturally contaminated with mycotoxins

Chen

2009

Front. Agric. China

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“…Satratoxin H-Induced Lipid Peroxidation in PC12 Cells Trichothecenes have been shown to induce lipid peroxidation in vivo in the liver and brain, 23,34,35) and in vitro in the human intestinal cell line Caco-2. 36) Since lipid peroxidation is secondary to ROS generation, 37) we measured lipid peroxidation by the TBARS method.…”

Section: Effect Of Satratoxin H On Cell Death Of Pc12 Cellsmentioning

confidence: 99%

Satratoxin H Generates Reactive Oxygen Species and Lipid Peroxides in PC12 Cells

Nusuetrong

Pengsuparp

Meksuriyen

et al. 2008

Biological & Pharmaceutical Bulletin

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Satratoxin H, a mycotoxin, is thought to induce apoptosis of PC12 cells through the activation of p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) in a glutathione (GSH)-sensitive manner. The present study was undertaken to further elucidate the mechanism by which satratoxin H induces cell death in PC12 cells. Satratoxin H caused apoptosis of PC12 cells within 24-h, as determined by DNA fragmentation and flow cytometric analysis. Satratoxin H increased reactive oxygen species (ROS) production and lipid peroxidation, as determined by malondialdehyde formation. These effects were attenuated by incubation of cells with GSH, suggesting that satratoxin H-induced increase in apoptosis of serum-deprived PC12 cells may be partially mediated through the generation of ROS.

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“…Moreover, T-2 toxin can bind to the eukaryotic 60S ribosomal subunit causing inhibition of protein, DNA, and RNA synthesis. 30,31 Through the rich metaphyseal open capillary network, T-2 toxin can inhibit the proliferation of cartilage cells and reduce synthesis of proteoglycan and collagen. Thus, the mycotoxins that are seen as exogenous free-radical carriers are important environmental factors in the pathogenesis of KBD.…”

Section: Discussionmentioning

confidence: 99%

Cartilage oligomeric matrix protein in serum and epiphyseal plate in Kashin-Beck disease

Yan¹,

Song²,

Pei³

2013

Current Orthopaedic Practice

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Effect of T-2 toxin on in vivo lipid peroxidation and vitamin E status in mice

Cited by 57 publications

References 25 publications

Protective effects of selenium and vitamin E on rats consuming maize naturally contaminated with mycotoxins

Protective effects of selenium and vitamin E on rats consuming maize naturally contaminated with mycotoxins

Satratoxin H Generates Reactive Oxygen Species and Lipid Peroxides in PC12 Cells

Cartilage oligomeric matrix protein in serum and epiphyseal plate in Kashin-Beck disease

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