Effect of Ta2O5 content on the osseointegration and cytotoxicity behaviors in hydroxyapatite-Ta2O5 coatings applied by EPD on superelastic NiTi alloys

Horandghadim, Nazila; Khalil‐Allafi, Jafar; Ürgen, Mustafa

doi:10.1016/j.msec.2019.05.005

Cited by 48 publications

(16 citation statements)

References 67 publications

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“…22 In Figure 5, HA/Ta composites show an increase in shrinkage when the sintering temperature is increased, which could result in the closure of some surface pores, extenuates the fluid penetration and consequently enhances the contact angle. 25,26 The second reason is associated with the phase composition. It has been reported that the contact angle increases with the increasing TCP concentration in the case of biphasic ceramic consisting of HA and β-TCP.…”

Section: → + +mentioning

confidence: 99%

Fabrication of Hydroxyapatite/Tantalum Composites by Pressureless Sintering in Different Atmosphere

Cai

Wang

et al. 2021

ACS Omega

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The effect of sintering atmosphere (air and Ar) and temperature (1100, 1200, 1300 °C) on the microstructure, mechanical properties, and bioactivity of hydroxyapatite/tantalum (HA/Ta) composites were systematically investigated by pressureless sintering of the mixture of HA and Ta powders. It shows that the sintering atmosphere greatly impacts the phase composition and microstructure of the HA/Ta composites. The higher diffusion of atoms promotes shrinkage and causes deeper reaction fusion between the HA matrix and Ta, which improved the interfacial binding of the HA/Ta composites. The refined grain structure and improved interfacial binding obtained within the Ar atmosphere compared to the air atmosphere benefit the mechanical properties. The maximum bending strength and shrinkage observed for the composites sintered at 1300 °C in the Ar atmosphere are 27.24 MPa and 6.65%, respectively. The cell counting kit-8 (CCK-8) method was used to investigate the in vitro cytocompatibility of HA/Ta composites. The results revealed that the HA/Ta composites sintered with different conditions have no cytotoxicity. The simulated body fluid (SBF) soaking results showed that all of the studied composites possess desirable bioactivity, as demonstrated by their ability to form calcium-deficient carbonate apatite layer on the surfaces. For composites sintered at 1300 °C, the surface apatite layer coverage of the composites obtained in the Ar atmosphere was increased by 139.7% than the ones obtained in air, which confirmed an enhanced bioactive mineralization ability. The results indicated that the HA/Ta composites sintered at 1300 °C in Ar possess desirable mechanical properties and bioactivity. This work opens up the new possibility for preparing HA-based composites and is of great value in biomedical applications.

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Section: → + +mentioning

confidence: 99%

Fabrication of Hydroxyapatite/Tantalum Composites by Pressureless Sintering in Different Atmosphere

Cai

Wang

et al. 2021

ACS Omega

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“…Among the common metallic biomaterials, stainless steels can suffer from a lack of bioactivity. 34 − 40 …”

Section: Introductionmentioning

confidence: 99%

Progress in Niobium Oxide-Containing Coatings for Biomedical Applications: A Critical Review

et al. 2022

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Typically, pure niobium oxide coatings are deposited on metallic substrates, such as commercially pure Ti, Ti6Al4 V alloys, stainless steels, niobium, TiNb alloy, and Mg alloys using techniques such as sputter deposition, sol–gel deposition, anodizing, and wet plasma electrolytic oxidation. The relative advantages and limitations of these coating techniques are considered, with particular emphasis on biomedical applications. The properties of a wide range of pure and modified niobium oxide coatings are illustrated, including their thickness, morphology, microstructure, elemental composition, phase composition, surface roughness and hardness. The corrosion resistance, tribological characteristics and cell viability/proliferation of the coatings are illustrated using data from electrochemical, wear resistance and biological cell culture measurements. Critical R&D needs for the development of improved future niobium oxide coatings, in the laboratory and in practice, are highlighted.

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Section: Introductionmentioning

confidence: 99%

“…20 TP has been incorporated into the hydroxyapatite and bioglass to improve bioactivity and mechanical strengths. 21 Therefore, the noteworthy attributes of TP (eg, outstanding biocompatibility, bioactivity, and corrosion resistance as well as high hydrophilicity) exhibited its advantages for bone regeneration. 22 As a dental implant in vivo, it should be closely combined with not only bone tissue to obtain osseointegration but also gingival tissue to achieve bio-sealing.…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Coating of Non-Crystalline Tantalum Pentoxide on Polyetheretherketone Enhances RBMS Cells/HGE Cells Adhesion

Pang¹,

Pan²,

Ma³

et al. 2021

IJN

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Purpose As a dental material, polyetheretherketone (PEEK) is bioinert that does not induce cellular response and bone/gingival tissues regeneration. This study was to develop bioactive coating on PEEK and investigate the effects of coating on cellular response. Materials and Methods Tantalum pentoxide (TP) coating was fabricated on PEEK surface by vacuum evaporation and responses of rat bone marrow mesenchymal stem (RBMS) cells/human gingival epithelial (HGE) were studied. Results A dense coating (around 400 nm in thickness) of TP was closely combined with PEEK (PKTP). Moreover, the coating was non-crystalline TP, which contained many small humps (around 10 nm in size), exhibiting a nanostructured surface. In addition, the roughness, hydrophilicity, surface energy, and protein adsorption of PKTP were remarkably higher than that of PEEK. Furthermore, the responses (adhesion, proliferation, and osteogenic gene expression) of RBMS cells, and responses (adhesion and proliferation) of HGE cells to PKTP were remarkably improved in comparison with PEEK. It could be suggested that the nanostructured coating of TP on PEEK played crucial roles in inducing the responses of RBMS/HGE cells. Conclusion PKTP with elevated surface performances and outstanding cytocompatibility might have enormous potential for dental implant application.

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Effect of Ta2O5 content on the osseointegration and cytotoxicity behaviors in hydroxyapatite-Ta2O5 coatings applied by EPD on superelastic NiTi alloys

Cited by 48 publications

References 67 publications

Fabrication of Hydroxyapatite/Tantalum Composites by Pressureless Sintering in Different Atmosphere

Fabrication of Hydroxyapatite/Tantalum Composites by Pressureless Sintering in Different Atmosphere

Progress in Niobium Oxide-Containing Coatings for Biomedical Applications: A Critical Review

Nanostructured Coating of Non-Crystalline Tantalum Pentoxide on Polyetheretherketone Enhances RBMS Cells/HGE Cells Adhesion

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