Effect of Tea (<i>Camellia sinensis</i>) and Olive (<i>Olea europaea</i>L.) Leaves Extracts on Male Mice Exposed to Diazinon

Al-Attar, Atef M.; Zeid, Isam M. Abu

doi:10.1155/2013/461415

Cited by 48 publications

(39 citation statements)

References 31 publications

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“…Diazinon, an organophosphrus insecticide, has been widely used in industrial, veterinary, and agriculture practice, that would be potentially an exposure risk to animals and human as well (Larkin and Tjeerdema 2000). Although several investigations about DZN toxicity have been published, little study has been performed about the preventive agents used against such a toxicity and mechanism of their ameliorative action (Larkin and Tjeerdema 2000;Al-Attar and Abu Zeid 2013;Razavi et al 2013;Elmazoudy et al 2011;ElMazoudy and Attia 2012). In the present study, the renal injuries caused by DZN may be caused by the oxidative stress resulted from free radical production.…”

Section: Discussionmentioning

confidence: 66%

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

Abdel-Daim

2014

Cytotechnology

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Diazinon (DZN) is a synthetic organophosphrus acaricide and insecticide widely used for veterinary and agricultural purposes. However, its animal and human exposure leads to nephrotoxicity. Our experimental objective was to evaluate protective effects of ceftriaxone and/or ascorbic acid-vitamin C against DZN-induced renal injury in male Wistar albino rats. DZN-treated animals revealed significant elevation in serum biochemical parameters related to renal injury: urea, uric acid and creatinine. DZN intoxication significantly increased renal lipid peroxidation, and significant inhibition in antioxidant biomarkers including, reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase and total antioxidant capacity. In addition, DZN significantly reduced serum acetylcholinestrase level. Moreover, It induced serum and kidney tumor necrosis factor-a level. Both ceftriaxone and vitamin C protect against DZN-induced serum as well as renal tissue biochemical parameters when used alone or in combination along with DZN-intoxication. Furthermore, both ceftriaxone and vitamin C produced synergetic nephroprotective and antioxidant effects. Therefore, it could be concluded that ceftriaxone and/or vitamin C administration are able to minimize the toxic effects of DZN by its free radical-scavenging and potent antioxidant activity.

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Section: Discussionmentioning

confidence: 66%

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

Abdel-Daim

2014

Cytotechnology

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“…Al-Attar and Abu Zeid [181] found that exposure of mice to 6.5 mg/kg body weight of diazinon for seven weeks resulted in statistical increases in serum alkaline phosphatase activity and creatinine level.…”

Section: Olive Tree (Olea Europaea)mentioning

confidence: 99%

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Azab¹,

Albasha²,

Elsayed³

2017

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Nephrotoxicity is one of the most common kidney problems and occurs when the body is exposed to a drug or toxin. Natural sources of antioxidants may serve as a vital source of potentially useful new compounds for the development of an effective therapy to combat a variety of kidney problems. Natural antioxidants have a variety of biochemical actions such as inhibition of reactive oxygen species production, scavenging of free radicals. The present review aims to summarize the recent articles which studied some of the nephrotoxic agents, and alleviation of nephrotoxicity using of some natural products possessing antioxidant properties. Our review shows the oxidative damage and renal disorders induced in human and experimental animals by nephrotoxic agents such as gentamicin, alcohol, nicotine, adenine, glycerol, ethylene glycol, sodium nitrite, mercuric chloride, AlCl 3 , lead acetate, carbon tetrachloride (CCl 4 ), furosemide, carbendazim, diazinon, heat stress, and γ-radiation. Also, nephrotic disorders caused in diabetic rats, patients, cirrhotic ascetic patients, and ischemia-reperfusion. Administration of natural sources of antioxidants such as curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame attenuated both physiological and histopathological alterations induced in the kidney by the nephrotoxic agent and certain diseases. The nephroprotective effect of the former natural sources of antioxidants may be due to the enhancement of antioxidant activity and inhibition of tissue lipid peroxidation. It can be concluded that administration of curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame showed a remarkable kidney protection against nephrotoxic agents, and diseases induced renal dysfunctions in human and experimental animals. So, the present study recommended that the consumption of these natural sources of antioxidants may be useful for human exposure to nephrotoxic agents and patients who suffer from renal diseases.

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“…The solution of olive leaves was filtered, and finally, the filtrates were evaporated in an oven at 40°C to produce dried residues (active principles). Furthermore, these extracts were prepared every 2 weeks and stored in a refrigerator for experimentation (Al-Attar & Abu Zeid, 2013). The polyphenol compounds of olive leaf extract were established by using chromatographic analysis using GC-MS in center lab of Ain Shams University, Faculty of science.…”

Section: Preparation Of Aqueous Olive Leaf Extract and Polyphenol Conmentioning

confidence: 99%

Influences of olive leaf extract in the kidney of diabetic pregnant mice and their offspring

Mohammed

Okail

Ibrahim

et al. 2018

JoBAZ

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Background: Phytotherapeutic treatment is used in the treatment of diabetes and its complications. The current study aims to evaluate the significant effect of supplementation of aqueous olive leaf extract (OLE) (Olea europaea) in the kidney of diabetic pregnant mice and their fetuses. Forty pregnant mice were divided into four groups contained 10 mice each after mating. The first group was the control (G1). The second group (GII) was intraperitoneally injected by a single dose of (240 mg/kg body weight) of streptozotocin (STZ). The third group (GIII) was administrated with a daily oral dose of extract of olive leaf extract (100 mg/kg) from days 1 to 18 of gestation. The fourth group (GIV) was injected intraperitoneally by a single dose of (240 mg/kg body weight) of STZ and post-treatment with oral dose of extract of olive leaves from days 1 to day 18 of gestation. Results: Both mothers and their fetuses of STZ-induced diabetic group showed a decrease in weight compared to control and diabetic group supplemented OLE extract. According to the biochemical and histopathological observations, the STZ-induced diabetic group showed a significant (P < 0.05) increase in serum urea and creatinine levels parallel with detectable histopathological changes in kidney tissues of pregnant mice and their fetuses. Moreover, there was a significant decrease in serum urea and creatinine (P < 0.05) of diabetic mother group under treatment with OLE as compared to diabetic mice. Also, histological findings showed improved renal architecture as reflected by reduced glomerular and tubular necrosis in pregnant mice and their fetuses when compared with control group. Also, there was an increase in the anti-angiotensin II (Ang II) immunoreactivity in renal tubules, intraglomerular, and interstitial cells in the kidney tissue of STZ-induced diabetic group which was markedly improved by treatment with OLE.

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Effect of Tea (Camellia sinensis) and Olive (Olea europaeaL.) Leaves Extracts on Male Mice Exposed to Diazinon

Cited by 48 publications

References 31 publications

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Influences of olive leaf extract in the kidney of diabetic pregnant mice and their offspring

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