Effect of testosterone and a nutritional supplement, alone and in combination, on hospital admissions in undernourished older men and women

Chapman, Ian; Visvanathan, Renuka; Hammond, Angela; Morley, John E.; Field, John; Tai, Kamilia; Belobrajdic, Damien P.; Chen, Richard Y. T.; Horowitz, Michael

doi:10.3945/ajcn.2008.26538

Cited by 88 publications

(34 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Malnutrition needs to be identified and treated effectively, since failure to do so can lead to disease complications and delay recovery from illness, at Elderly hospital discharges (49) Hip fracture hospital discharges (51) Elderly hospital discharges (50) Elderly hospital discharges (47) Benign GI disease (48) Elderly community (52) Routine care ONS % admitted to hospital * * Fig. 3.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, two large RCT have highlighted significant reductions in hospital readmissions following the use of ONS in community settings, in older people with a wide range of conditions and in individuals with benign gastrointestinal disease (46,47) . Other trials have also shown lower (not significantly so) hospital admissions/readmissions with the use of ONS v. routine care (48)(49)(50)(51) (Fig. 3).…”

Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

See 1 more Smart Citation

Encouraging appropriate, evidence-based use of oral nutritional supplements

Stratton

Elia

2010

Proc. Nutr. Soc.

View full text Add to dashboard Cite

With the considerable cost of disease-related malnutrition to individuals and to society (estimated to be > £13 · 10 9 for the UK, 2007 prices), there is a need for effective and evidence-based ways of preventing and treating this condition. The wide range of oral nutritional supplements that may be prescribed for the dietary management of malnutrition and other conditions account for only about 1 % (about £99 · 10 6 , 2007 data) of the prescribing budget in England. Systematic reviews and meta-analyses consistently suggest that ready-made, multinutrient liquids which may be prescribed can improve energy and nutritional intake, body weight and have a variety of clinical and functional benefits in a number of patient groups. Meta-analyses have repeatedly shown that oral nutritional supplements produce significant reductions in complications (e.g. infections) and mortality, and a recent meta-analysis shows a reduction in hospital admissions (OR 0 . 56 (95% CI 0 . 41, 0 . 77), six randomised controlled trials). Such benefits suggest that the appropriate use of oral nutritional supplements should form an integral part of the management of malnutrition, particularly as there is currently a lack of evidence for alternative oral nutrition strategies (e.g. food fortification and counselling). As with all therapies, compliance to oral nutritional supplements needs to be maximised and the use monitored. To make sure that those at risk of malnutrition are identified and treated appropriately, there is a need to embed national and local policies into routine clinical practice. In doing so, the economic burden of this costly condition can be curtailed. As recently suggested by the National Institute for Health and Clinical Excellence, substantial cost savings could be made if screening and treatment of malnourished patients was undertaken.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

Encouraging appropriate, evidence-based use of oral nutritional supplements

Stratton

Elia

2010

Proc. Nutr. Soc.

View full text Add to dashboard Cite

show abstract

“…In the study by Caminiti et al [64], HF did occur but was easily treatable with slight increases in the furosemide dose. In addition, Chapman et al [86] found a decrease in hospitalisations in frail males and females receiving low dose testosterone.…”

Section: Testosterone and Arrhythmiamentioning

confidence: 99%

Testosterone replacement therapy and cardiovascular risk factors modification

2011

View full text Add to dashboard Cite

Hypogonadism in males is associated with increased atherosclerotic disease. Physiologically, testosterone appears to have both positive and negative effects on the cardiovascular system. Testosterone decreases angina and may improve the cardiac healing response after myocardial infarction. Testosterone enhances function in males with heart failure (HF). Testosterone causes water retention and oedema is common in older persons. Oedema should not be used to diagnose HF in older persons. Studies in older persons with HF and frailty have shown a non-statistically lower mortality rate compared to those receiving placebo.

show abstract

“…in these studies there have been more deaths in the placebo compared to the treatment group. a single study in assisted living found that testosterone with a caloric supplement decreased hospitalizations (88).…”

Section: Managementmentioning

confidence: 99%

Frailty: Diagnosis and management

Morley

2011

The Journal of nutrition, health and aging

View full text Add to dashboard Cite

Effect of testosterone and a nutritional supplement, alone and in combination, on hospital admissions in undernourished older men and women

Cited by 88 publications

References 44 publications

Encouraging appropriate, evidence-based use of oral nutritional supplements

Encouraging appropriate, evidence-based use of oral nutritional supplements

Testosterone replacement therapy and cardiovascular risk factors modification

Frailty: Diagnosis and management

Contact Info

Product

Resources

About